The effect of extracellular ATP on LPS-induced endotoxin shock in mice.

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Extracellular ATP leads to immune responses in a wide spectrum of cell types (e.g., macrophages, T cells) and tissues. However, it remains unclear whether such ATP-activated macrophages modulate the magnitude of immune responses to actual tissue injury. Thus, we investigated the role of ATP-mediated inflammatory response by macrophages in LPS-induced endotoxin shock. This study indicated that the binding of extracellular ATP to P2purinergic receptors on macrophages increases neutrophil infiltration via the production of MIP-2. However, in this pathway, further examination was required because P2purinergic receptor of the having many kinds was related.