Analysis of the interaction between enteropathogenic Escherichia coli infection and mucosal immunity in vitro and in vivo

本研究旨在探讨肠致病性大肠杆菌（EPEC）与宿主粘膜免疫反应的相互作用。因此，我们发现Peyer集合淋巴结对于C57 BL/6小鼠的细菌定植是重要的，而不是Balb/c小鼠。然后利用骨髓来源的树突状细胞和上皮细胞建立体外感染模型。因此，EPEC的III型分泌系统直接或间接地调节树突状细胞上各种基因的表达。

The aim of this study is to investigate the interaction between enteropathogenic E.coli (EPEC) and host mucosal immune response. Consequently, we found that Peyer's patch was important for bacterial colonization in C57BL/6 mouse but not Balb/c mouse. And then we performed the in vitro infection model using bonemarrow derived dendritic cells and epithelial cells. Consequently, type III secretion system of EPEC directly or indirectly regulated the expression of various genes on dendritic cells.