Development of "microRNA-regulating chemoprevention"

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miR-34a is a tumor suppressor microRNA. I searched for the food components that regulated miR-34a expression. As a result from flow cytometry analysis, several kinds of materials inducing G1 arrest were found, using RB inactivated cancer cells.Real-time PCR specified flavone that induced miR-34a expression from candidate materials. In addition, decrease in target proteins of miR-34a was confirmed by Western blot analysis.These results suggested that food component could control expression of microRNA in vivo. The research of miR-34a regulated by flavone might realize "microRNA-regulating chemoprevention"