Development of "microRNA-regulating chemoprevention in cancer"

我搜索了调节microRNA表达的食物成分。流式细胞仪分析的结果是，在RB灭活的癌细胞中发现了黄酮类，在突变的RB细胞系中，黄酮类增加了磷酸化的RB家族蛋白p130和p107。已知的miR-34a下调了miR-34a对肿瘤抑制基因miR-34a的抑制作用，提示miR-34a可能部分参与了黄酮类药物对G1期的抑制作用。研究黄酮调控的miR-34a有可能实现“microRNA调控的癌症化学预防”。

I searched for the food components that regulated microRNA expression. As a result from flow cytometry analysis, flavone was found, using RB inactivated cancer cells.In mutated RB cell line, flavone increased phosphorylated RB family proteins p130 and p107. Flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G1 arrest by flavone.These results suggested that food component could control expression of microRNA invivo. The research of miR-34a regulated by flavone might realize “microRNA-regulating chemoprevention in cancer”.