The validation of epidemiologic significance in measurment of serum vaspin levels associated with metabolic syndrome

代谢综合征相关血清 Vaspin 水平测量的流行病学意义验证

• 批准号: 21790590
• 负责人: ESAKI Eishi
• 金额: $ 2.75万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790590/
• 关键词: アディポサイトカイン; 内臓脂肪蓄積; インスリン抵抗性; 動脈硬化

Recently, metabolic syndrome (MetS) has gathered the great attention as the cause of cardiometabolic diseases. Serum levels of vaspin (Visceral adipose tissue-derived serin protease inhibitor) is associated with insulin resistance based on visceral adipocity, and it was demonstrated that vaspin might have a potentially insulin-sensitizing effects in experimental animal models. In this cross sectional study for Japanese general population, vaspin serum concentrations were positively associated with body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and intima-media thickness of common carotid artery (IMT) on B-mode ultrasonography. However, a further investigation is needed to evaluate the predicted causal relationship between vaspin and development of the visceral obesity-associated metabolic disorders, and to testify the utility of vaspin as a biomarker. Therefore, the data correction has currently been ongoing in 2011.

近年来，代谢综合征（MetS）作为心血管代谢疾病的病因引起了广泛关注。vaspin（内脏脂肪组织来源的丝氨酸蛋白酶抑制剂）的血清水平与基于内脏脂肪化的胰岛素抵抗相关，并且在实验动物模型中证明vaspin可能具有潜在的胰岛素增敏作用。在这项针对日本普通人群的横断面研究中，vaspin血清浓度与体重指数（BMI）、胰岛素抵抗的稳态模型评估（HOMA-IR）和B型超声检查显示的颈总动脉（IMT）内膜中层厚度呈正相关。然而，需要进一步的研究来评估预测的因果关系之间的vaspin和内脏肥胖相关的代谢紊乱的发展，并证明vaspin作为生物标志物的效用。因此，2011年的数据更正工作目前正在进行。

项目成果

Serum Vaspin Levels Are Positively Associated with Cardiometabolic Risks in a General Population

一般人群中血清 Vaspin 水平与心脏代谢风险呈正相关

• 发表时间: 2009
• 作者: Eishi Esaki;Hisashi Adachi;Mika Enomoto;Ako Fukami;Akira Satoh;Shun-ichi Kumagae;Maki Otsuka;Yasuki Nanjo;Kumiko Furuki;Eita Kumagai;Kuniko Yoshikawa;Akiko;Kasahara;Eri Tsukagawa;Kinuka Ogata;Kanako Yokoi;Kyoko Murayama;Tsutomu Imaizumi
• 通讯作者: Tsutomu Imaizumi

血漿vaspin濃度と動脈硬化の関連について~一般住民検診の結果より~

关于血浆vaspin浓度与动脉硬化的关系～基于一般人群检查结果～

• 发表时间: 2011
• 作者: Eishi Esaki;Hisashi Adachi;Mika Enomoto;Ako Fukami;Akira Satoh;Shun-ichi Kumagae;Maki Otsuka;Yasuki Nanjo;Kumiko Furuki;Eita Kumagai;Kuniko Yoshikawa;Akiko;Kasahara;Eri Tsukagawa;Kinuka Ogata;Kanako Yokoi;Kyoko Murayama;Tsutomu Imaizumi
• 通讯作者: Tsutomu Imaizumi

Serum vaspin levels are positively associated with metabolic syndrome and subclinical atherosclerosis in a general population where obesity is rare

在肥胖罕见的普通人群中，血清 vaspin 水平与代谢综合征和亚临床动脉粥样硬化呈正相关

• 发表时间: 2009
• 作者: Eishi Esaki;Hisashi Adachi;Mika Enomoto;Ako Fukami;Akira Satoh;Shun-ichi Kumagae;Maki Otsuka;Yasuki Nanjo;Kumiko Furuki;Eita Kumagai;Kuniko Yoshikawa;Akiko;Kasahara;Eri Tsukagawa;Kinuka Ogata;Kanako Yokoi;Kyoko Murayama;Tsutomu Imaizumi
• 通讯作者: Tsutomu Imaizumi

血漿vaspin濃度測定の心血管リスク評価への応用の可能性

血浆 vaspin 浓度测量应用于心血管风险评估的可能性

• 发表时间: 2011
• 作者: Eishi Esaki;Hisashi Adachi;Mika Enomoto;Ako Fukami;Akira Satoh;Shun-ichi Kumagae;Maki Otsuka;Yasuki Nanjo;Kumiko Furuki;Eita Kumagai;Kuniko Yoshikawa;Akiko;Kasahara;Eri Tsukagawa;Kinuka Ogata;Kanako Yokoi;Kyoko Murayama;Tsutomu Imaizumi
• 通讯作者: Tsutomu Imaizumi

血漿vaspin濃度は一般住民において無症候性アテローム性動脈硬化症と正の相関を示す

一般人群血浆 vaspin 浓度与亚临床动脉粥样硬化呈正相关

• 发表时间: 2010
• 作者: Eishi Esaki;Hisashi Adachi;Mika Enomoto;Ako Fukami;Akira Satoh;Shun-ichi Kumagae;Maki Otsuka;Yasuki Nanjo;Kumiko Furuki;Eita Kumagai;Kuniko Yoshikawa;Akiko;Kasahara;Eri Tsukagawa;Kinuka Ogata;Kanako Yokoi;Kyoko Murayama;Tsutomu Imaizumi;江崎英司
• 通讯作者: 江崎英司