Analysis of Notch-mediated regeneration of the intestinal epithelia

Notch介导的肠上皮再生分析

• 批准号: 21790651
• 负责人: OKAMOTO Ryuichi
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790651/
• 关键词: 腸管粘膜; Notchシグナル; 上皮再生; 炎症性腸疾患; 杯細胞; Hath1; Hes1; 粘膜再生; Olfm4; 幹細胞; Deltaリガンド; γ-セクレターゼ阻害剤; MUC2; 腸管上皮細胞

Our current study revealed the role of Notch signaling not only in homeostasis of the intestinal epithelial tissue, but also in tissue regeneration, through regulation of epithelial cell proliferation and differentiation. In addition, we showed that among Notch ligands, Jag1, Dll1 and Dll4 are expressed in the human intestinal epithelial tissue, suggesting their involvement in regulation of epithelial cell differentiation. These results provide a novel basis for the establishment of therapeutic approaches aimed to promote mucosal regeneration of refractory inflammatory bowel disease patients.

我们目前的研究揭示了Notch信号不仅在肠上皮组织的体内稳态中的作用，而且还通过调节上皮细胞增殖和分化而在组织再生中的作用。此外，我们表明，在人类肠上皮组织中表达的凹槽配体中，JAG1，DLL1和DLL4表达，这表明它们参与了调节上皮细胞分化的调节。这些结果为建立旨在促进难治性炎症性肠病患者粘膜再生的治疗方法提供了新的基础。

项目成果

Notch1 activation promotes goblet cell depletion and expression of PLA2G2A in the inflamed mucosa of ulcerative colitis

Notch1激活促进溃疡性结肠炎发炎粘膜中杯状细胞的消耗和PLA2G2A的表达

• 发表时间: 2009
• 作者: 秋山純子;岡本隆一;岡本隆一
• 通讯作者: 岡本隆一

Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.

肠上皮细胞中通过 TNF-α/NF-κB 的信号通路可能直接参与结肠炎相关的癌变。

• 发表时间: 2009
• 期刊: Am J Physiol Gastrointest Liver Physiol. 296
• 作者: Onizawa M;Okamoto R;Nakamura T;Watanabe M(他12名、9番目)
• 通讯作者: Watanabe M(他12名、9番目)

Long-Lived Colitogenic CD4+ Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis

• DOI: 10.4049/jimmunol.0803684
• 发表时间: 2009-10-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Nemoto, Yasuhiro;Kanai, Takanori;Watanabe, Mamoru
• 通讯作者: Watanabe, Mamoru

Expression of Delta ligands is regulated by Notch-Hes1 signaling pathway in human intestinal epithelial cells

人肠上皮细胞中Notch-Hes1信号通路调控Delta配体的表达

• 发表时间: 2009
• 作者: 秋山純子;岡本隆一
• 通讯作者: 岡本隆一

TNF-α and Notch signaling synergistically up-regulate OLFM4 expression in human intestinal epithelial cells

TNF-α 和 Notch 信号协同上调人肠上皮细胞中 OLFM4 的表达

• 发表时间: 2010
• 作者: Okamoto R.;et al.
• 通讯作者: et al.