The molecular mechanism focused on calcium in pathogenesis of heart failure and its clinical application.

重点关注钙在心力衰竭发病机制中的分子机制及其临床应用。

• 批准号: 21790723
• 负责人: TAKEDA Toshihiro
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790723/
• 关键词: 分子心臓病態学; カルシウム; 興奮収縮連関; ノックアウトマウス; 循環器・高血圧; 蛋白質; 動物; 心筋細胞

In the heart, calcium plays important roles in excitation-contraction (E-C) coupling. SERCA2a and ryanodine receptor (RyR2) are two major Ca^<2+> signaling proteins involving in E-C coupling. The activity of these proteins is regulated by their accessory proteins, which may play an important role in the pathogenesis of heart failure. Sorcin is the one of the protein that is associated with RyR2The expression level of sorcin was altered in remodeling hearts. In order to elucidate a role of sorcin in the heart, we generated sorcin knockout mice. The mice showed no abnormal E-C coupling.

在心脏中，钙在兴奋-收缩（E-C）偶联中起重要作用。SERCA 2a和Ryanodine受体（RyR2）是两种主要的Ca ^2+信号蛋白，参与了E-C偶联。这些蛋白的活性受其辅助蛋白的调节，这些辅助蛋白可能在心力衰竭的发病机制中起重要作用。Sorcin是与RyR 2相关的蛋白质之一。为了阐明sorcin在心脏中的作用，我们产生了sorcin敲除小鼠。小鼠没有表现出异常的E-C偶联。

项目成果

ヘモグロビン酸素親和性に着目した心不全患者運動耐容能改善の試み

尝试提高心力衰竭患者的运动耐量，重点关注血红蛋白氧亲和力

• 发表时间: 2009
• 作者: 楠瀬賢也;他;牧山武;武田理宏;武田理宏
• 通讯作者: 武田理宏

Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.

MTK1/MEKK4 的激活会诱导心肌细胞死亡和心力衰竭。

• 发表时间: 2010
• 期刊: Journal of Molecular and Cellular Cardiology 48
• 作者: Mizote I;Yamaguchi O;Hikoso S;Takeda T;et al.
• 通讯作者: et al.

Allosteric Modulation of Hemoglobin is the New Therapeutic Target for Improving Exercise Capacity in Patients with Chronic Heart Failure.

血红蛋白的变构调节是改善慢性心力衰竭患者运动能力的新治疗目标。

• 发表时间: 2009
• 作者: 楠瀬賢也;他;牧山武;武田理宏
• 通讯作者: 武田理宏

Reduction in Hemoglobin-Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice with Chronic Heart Failure.

血红蛋白-氧亲和力的降低导致慢性心力衰竭小鼠运动能力的提高。

• 发表时间: 2009
• 作者: 楠瀬賢也;他;牧山武;武田理宏;武田理宏;武田理宏;武田理宏
• 通讯作者: 武田理宏

The IκB Kinase β/Nuclear Factor κB Signaling Pathway Protects the Heart From Hemodynamic Stress Mediated by the Regulation of Manganese Superoxide Dismutase Expression

• DOI: 10.1161/circresaha.108.193318
• 发表时间: 2009-07-02
• 期刊: CIRCULATION RESEARCH
• 影响因子: 20.1
• 作者: Hikoso, Shungo;Yamaguchi, Osamu;Otsu, Kinya
• 通讯作者: Otsu, Kinya