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The molecular mechanism focused on calcium in pathogenesis of heart failure and its clinical application.

The molecular mechanism focused on calcium in pathogenesis of heart failure and its clinical application.
重点关注钙在心力衰竭发病机制中的分子机制及其临床应用。
批准号:
21790723
负责人:
TAKEDA Toshihiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
In the heart, calcium plays important roles in excitation-contraction (E-C) coupling. SERCA2a and ryanodine receptor (RyR2) are two major Ca^<2+> signaling proteins involving in E-C coupling. The activity of these proteins is regulated by their accessory proteins, which may play an important role in the pathogenesis of heart failure. Sorcin is the one of the protein that is associated with RyR2The expression level of sorcin was altered in remodeling hearts. In order to elucidate a role of sorcin in the heart, we generated sorcin knockout mice. The mice showed no abnormal E-C coupling.
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会议论文
ヘモグロビン酸素親和性に着目した心不全患者運動耐容能改善の試み
尝试提高心力衰竭患者的运动耐量,重点关注血红蛋白氧亲和力
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [楠瀬賢也, 他, 牧山武, 武田理宏, 武田理宏]
通讯作者: 武田理宏
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
MTK1/MEKK4 的激活会诱导心肌细胞死亡和心力衰竭。
DOI: --
发表时间: 2010
期刊: Journal of Molecular and Cellular Cardiology 48
影响因子: --
作者: [Mizote I, Yamaguchi O, Hikoso S, Takeda T, et al.]
通讯作者: et al.
Allosteric Modulation of Hemoglobin is the New Therapeutic Target for Improving Exercise Capacity in Patients with Chronic Heart Failure.
血红蛋白的变构调节是改善慢性心力衰竭患者运动能力的新治疗目标。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [楠瀬賢也, 他, 牧山武, 武田理宏]
通讯作者: 武田理宏
Reduction in Hemoglobin-Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice with Chronic Heart Failure.
血红蛋白-氧亲和力的降低导致慢性心力衰竭小鼠运动能力的提高。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [楠瀬賢也, 他, 牧山武, 武田理宏, 武田理宏, 武田理宏, 武田理宏]
通讯作者: 武田理宏
6
    Modeling of medical process based on the goal-oriented ontological framework CHARM
    • 批准号:
      25460841
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2013
    • 负责人:
      TAKEDA Toshihiro
    • 依托单位:
    Development of new heart failure therapies that target oxygen metabolism
    • 批准号:
      23790850
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.66万
    • 财政年份:
      2011
    • 负责人:
      TAKEDA Toshihiro
    • 依托单位:
    海外基金