Development of new heart failure therapies that target oxygen metabolism

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The purpose of this study is to investigate the new chemicals that reduce hemoglobinoxygen affinity and improve the exercise intolerance of the patients with chronic heart failure from RSR13. RSR13 exerts its effect by fitting its aromatic ring in hemoglobinpocket. By enlarging the side chain of the aromatic ring of RSR13, the effect of new chemicals was increased. However, hemoglobin was denatured if the side chain was too large. In addition, by changing the skeleton RSR13, the effect of new chemicals were also increased.