Development of new heart failure therapies that target oxygen metabolism

开发针对氧代谢的新心力衰竭疗法

• 批准号: 23790850
• 负责人: TAKEDA Toshihiro
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790850/
• 关键词: ヘモグロビン; 酸素代謝; 運動耐容能; ヘモグロビン酸素親和性; 薬剤効果

The purpose of this study is to investigate the new chemicals that reduce hemoglobinoxygen affinity and improve the exercise intolerance of the patients with chronic heart failure from RSR13. RSR13 exerts its effect by fitting its aromatic ring in hemoglobinpocket. By enlarging the side chain of the aromatic ring of RSR13, the effect of new chemicals was increased. However, hemoglobin was denatured if the side chain was too large. In addition, by changing the skeleton RSR13, the effect of new chemicals were also increased.

本研究的目的是探讨新的化学物质，降低血红蛋白氧亲和力和改善运动不耐症的慢性心力衰竭患者从RSR13。RSR13通过将其芳环装配在血红蛋白口袋中发挥其作用。通过对RSR13的芳环侧链进行扩链，提高了新药剂的药效。然而，如果侧链太大，血红蛋白会变性。此外，通过改变RSR13的骨架，也增加了新的化学物质的效果。

项目成果

Calpain Protects the Heart from Hemodynamic Stress

• DOI: 10.1074/jbc.m111.248088
• 发表时间: 2011-09-16
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Taneike, Manabu;Mizote, Isamu;Otsu, Kinya
• 通讯作者: Otsu, Kinya