Development of a Novel Minimally Invasive Therapy Based on Pulse-infusion DDS Catheter for Coronary Arterial Diseases
Development of a Novel Minimally Invasive Therapy Based on Pulse-infusion DDS Catheter for Coronary Arterial Diseases
批准号:
21790732
负责人:
NAKANO Kaku
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We developed bio-absorbable nanoparticles which has efficacy drug delivery system. Furthermore, fluorescent marker incorporated nanoparticles were administrated into balloon injured rabbit and porcine coronary arteries using an infusion catheter system. Nanoparticles were observed and retentive until up to 28 days. Drug incorporated nanoparticles significantly attenuated neointimal formation as compared with vehicle control group.
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Nanoparticle-Mediated Delivery of Nuclear Factor κ_B Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial.
纳米颗粒介导的核因子 κ_B 诱饵进入肺部可改善野百合碱诱导的肺动脉。
DOI:
--
发表时间:
2009
期刊:
Hypertension. 53(5)
影响因子:
--
作者:
[Kimura S, et al.]
通讯作者:
et al.
Pitavastatin incorporated nanoparticle-eluting stents attenuate in-stent stenosis without anti-healing effects induced by sirolimus-eluting stents(Cypher)in porcine coronary artery model
匹伐他汀掺入纳米颗粒洗脱支架可减轻猪冠状动脉模型中西罗莫司洗脱支架 (Cypher) 引起的支架内狭窄,且不会产生抗愈合作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kaku Nakano, Tetsuya Matoba, Kenji Sunagawa, Kensuke Egashira]
通讯作者:
Kensuke Egashira
ナノテクノロジーを基盤としたナノDDSステントの開発とブタ冠動脈モデルにおけるピタバスタチンナノDDSステントの有効性と安全性
基于纳米技术的纳米DDS支架的研制及匹伐他汀纳米DDS支架在猪冠状动脉模型中的有效性和安全性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[中野覚, 他]
通讯作者:
他
Pitavastatin has most Potent Pro-healing Effects on Endothelial Cells and Inhibitory Effects on Proliferation of Vascular Smooth Muscle Cells -A Potential Treatment Strategy for Drug-Eluting Stents
匹伐他汀对内皮细胞具有最强的促愈合作用和对血管平滑肌细胞增殖的抑制作用——药物洗脱支架的潜在治疗策略
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kaku Nakano, Kensuke Egashira]
通讯作者:
Kensuke Egashira
Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology: Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.
采用阳离子电沉积涂层技术配制纳米颗粒洗脱支架:通过生物可吸收聚合物纳米颗粒洗脱支架在猪冠状动脉中高效、安全地输送纳米药物。
DOI:
--
发表时间:
2009
期刊:
J Am Coll Cardiol : Cardovasular Intervention. 2(4)
影响因子:
--
作者:
[Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S, Matoba T, Sueishi K, Endo Y, Kawashima Y, Hara K, Tsujimoto H, Tominaga R, Sunagawa K]
通讯作者:
Sunagawa K
共 20 条
Site Specific Delivery of Pitavastatin Using an Innovative Combination Drug Delivery System Attenuates Neointima Formation after PCI in Porcine Coronary Arteries
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批准号:23790863
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:NAKANO Kaku
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依托单位:
海外基金