Epigenetic analysis and establishment of novel therapy for heart failure

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We previously identified heart failure-specific epigenetic marks, trimethylation of histone H3 on lysine-4 (K4TM) or lysine-9 (K9TM) with using ChIP-on-chip analysis on the left ventricular cardiomyocytes of Dahl salt-sensitive rats which are genetically intolerant to excessive salt intake. In this project, we investigated whether administering an inhibitor of histone modifying enzyme which affects the trimethylation status on H3K9 ameliorates left ventricular dysfunction or not. Left ventricular contraction at failing stage has restored by administration of an inhibitor of H3K9 methyltransferase, Chaetocin. The inhibitor had a tendency to prolong survival term of animals. The intervention for heart failure-specific epigenetic alteration might become a novel therapeutic strategy for heart failure.