A novel function of Toll-like receptors on the water-electrolytes secretions from airway submucosal glands
A novel function of Toll-like receptors on the water-electrolytes secretions from airway submucosal glands
批准号:
21790761
负责人:
TAMADA Tsutomu
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
气道分泌物在生理和病理条件下都得到很好的控制。Toll样受体(TLR)识别不同的病原体相关分子模式并激活先天免疫应答。在本研究中,我们发现TLR4配体可以增强猪气管腺腺泡细胞的电解质分泌。这可能为将来控制气道分泌物提供新的治疗候选者。
英文摘要
Airway secretions are well controlled in both physiologic and pathologic conditions. Toll-like receptors (TLRs)recognize distinct pathogen associated molecular patterns and activate innate immune responses. In the present study, we showed that the TLR4 ligand could potentiate the secretion of electrolytes from swine tracheal gland acinar cells. This may offer a new therapeutic candidate for controlling airway secretions in the future.
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Toll like receptor 4 potentiates Ca2+ dependent electrolyte secretion from swine tracheal glands Am J Respir
Toll 样受体 4 增强猪气管腺 Ca2 依赖性电解质分泌 Am J Respir
DOI:
--
发表时间:
2011
期刊:
Cell Mol Biol
影响因子:
1.6
作者:
[Murakami K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira, Y. Maruyama, M. Ebina and T. Nukiwa.]
通讯作者:
M. Ebina and T. Nukiwa.
Toll-like receptor 4 signaling as a potentiator in the airway submucosal gland secretion.
Toll 样受体 4 信号传导作为气道粘膜下腺分泌的增强剂。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Murakami, K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira, M. Ebina and T. Nukiwa.]
通讯作者:
M. Ebina and T. Nukiwa.
The effects of clinically-used phosphodiesterase inhibitors on Ca2+-dependent electrolytes secretion from airway submucosal gland.
临床使用的磷酸二酯酶抑制剂对气道粘膜下腺Ca2依赖性电解质分泌的影响。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Muramatsu, S., T. Tamada, M. Nara, K. Murakami, M. Ebina and T. Nukiwa.]
通讯作者:
M. Ebina and T. Nukiwa.
Toll-like receptor signaling as a potentiator in the airway submucosal gland secretion.
Toll 样受体信号传导作为气道粘膜下腺分泌的增强剂。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Murakami, K., T.Tamada, 他]
通讯作者:
他
The effects of clinically-used phosphodiesterase inhibitors on Ca^<2+>-dependent electrolytes secretion from airway submucosal gland
临床应用磷酸二酯酶抑制剂对气道粘膜下腺Ca^2依赖性电解质分泌的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Muramatsu, S., T.Tamada, M.Nara, K.Murakami, M.Ebina, T.Nukiwa]
通讯作者:
T.Nukiwa
共 11 条
Establishment of MRI-guided planning in high-dose-rate brachytherapyof prostate cancer
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批准号:21591582
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:TAMADA Tsutomu
-
依托单位:
A potentiating effect of endogenous NO in the physiologic and pathologic secretion from airway submucosal glands
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批准号:18790526
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$0.74万
-
财政年份:2006
-
负责人:TAMADA Tsutomu
-
依托单位:
海外基金