Gene polymorphisms contributing to progression of chronic glomerulonephritis

导致慢性肾小球肾炎进展的基因多态性

• 批准号: 21790809
• 负责人: YAMAMOTO Ryohei
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790809/
• 关键词: 慢性糸球体腎炎; IgA腎症; 遺伝子多型; single nucleotide polymorphism (SNP); SNP; GPIa; ICAM-1; 動脈硬化; Single Nucleotide Polymorphism(SNP); GPIa C807T; GPIa G873A; ICAM-1 A1548G; PREDICT-IgAN

The aim of the present multicenter longitudinal cohort was identification of gene polymorphisms contributing to progression of chronic glomerulonephritis among 100 kinds of atherosclerotic diseases-related gene polymorphisms, mainly single Nucleotide Polymorphisms (SNPs). We determined 100 gene polymorphisms of 320 patients with IgA nephropathy, a most common chronic glomerulonephritis, and identified glycoprotein Ia (GPIa) C807T/G873A and intracellular adhesion molecule-1 (ICAM-1) A1548G(K469E) as significant predictors of progression of IgA nephropathy. Based on the clinical database of approximately 1000 patients with IgA nephropathy, we also revealed the number of cigarettes was a significant predictor of progression of IgA nephropathy. The results of the present study strongly suggested that atherosclerotic disease-related factors play pivotal roles in progression of IgA nephropathy, providing a deep insight into the treatment strategy of IgA nephropathy.

目前的多中心纵向队列的目的是在100种动脉粥样硬化性疾病相关基因多态中鉴定导致慢性肾小球肾炎进展的基因多态，主要是单核苷酸多态(SNPs)。我们检测了320例慢性肾小球肾炎患者的100个基因多态性，发现糖蛋白Ia(GPIa)C807T/G873A和细胞内黏附分子-1(ICAM-1)A1548G(K469E)是预测IgA肾病进展的重要因素。基于约1000名IgA肾病患者的临床数据库，我们还发现香烟数量是IgA肾病进展的重要预测因素。本研究结果有力地提示动脉粥样硬化性疾病相关因素在IgA肾病的进展中起着关键作用，为深入了解IgA肾病的治疗策略提供了依据。

项目成果

ホームページ等。

主页等

A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).

• DOI: 10.1093/ndt/gfp210
• 发表时间: 2009-12
• 期刊: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• 作者: Ryohei Yamamoto;Y. Nagasawa;T. Shoji;Kazunori Inoue;Takuya Uehata;T. Kaneko;Tomonori Okada;A. Yamauchi;Y. Tsubakihara;E. Imai;Y. Isaka;H. Rakugi

Microarray analysis of tonsils in immunoglobulin A nephropathy patients

• DOI: 10.1016/j.bbrc.2010.01.120
• 发表时间: 2010-03-19
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Iio, Kenichiro;Nagasawa, Yasuyuki;Rakugi, Hiromi
• 通讯作者: Rakugi, Hiromi

ICAM-1 A1548GとGPIa C807T/G873AはIgA腎症の腎予後関連因子である

ICAM-1 A1548G 和 GPIa C807T/G873A 是 IgA 肾病肾脏预后的相关因素

• 发表时间: 2009
• 作者: Ryohei Yamamoto;Yasuyuki Nagasawa;Tatsuya Shoji;Kazunori Inoue;Takuya Uehata;Tetsuya Kaneko;Noriyuki Okada;Atsushi Yamauchi;Yoshiharu Tsubakihara;Enyu Imai;Yoshiharu Isaka;Hiromi Rakugi;山本陵平
• 通讯作者: 山本陵平

Incidence of symptomatic stroke and cancer in chronic kidney disease patients treated with epoetins

• DOI: 10.1007/s10157-010-0308-x
• 发表时间: 2010-10-01
• 期刊: CLINICAL AND EXPERIMENTAL NEPHROLOGY
• 影响因子: 2.3
• 作者: Imai, Enyu;Yamamoto, Ryohei;Watanabe, Tsuyoshi
• 通讯作者: Watanabe, Tsuyoshi