The study of the molecular mechanism of polyglutamine disease model mice and search for new therapeutic molecule

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Using the expanded 155 polyglutamine overexpression transgenic mice, we analyzed the molecular mechanism of the mice from the early to end stage of the clinical course by sequential western blot analysis and immunofluorescence study. We revealed that the fragmentation of Golgi apparatus were occurred in early stage of the Tg mice. Further, we identified one of the Golgi related molecule was increased in protein expression level and the localization was different compared to the littermate NT mice at early stage.