Investigation of effect of GIGYF2 on signal transduction

GIGYF2已被报道为PARK11连锁帕金森病(PD)的候选基因。GIGYF2广泛表达，在胰腺和睾丸中高表达，在脑中中等水平表达。GIGYF2存在于Rab4阳性的内涵体中。GIGYF2的表达改变了胰岛素样生长因子-1(IGF-1)受体的转运，并增强了IGF-1诱导的ERK1/2的激活。我们没有发现表达野生型和突变型GIGYF2的细胞在IGF-1诱导的信号转导方面有任何差异，并且只观察到GIGYF2在黑质纹状体通路中的微量表达，表明GIGYF2在PD的发病机制中没有贡献。

GIGYF2 has been reported as a candidate gene for PARK11-linked Parkinson's disease (PD). GIGYF2 was widely expressed, most highly in the pancreas and testis, and moderately in brain. GIGYF2 was present in Rab4-positive endosomes. Expression of GIGYF2 altered insulin-like growth factor-1 (IGF-1) receptor trafficking and enhanced IGF-1-induced ERK1/2 activation. We failed to find any differences in IGF-1-induced signaling between cells expressing wild-type and mutant GIGYF2 and observed only minimal expression of GIGYF2 in the nigrostriatal pathway, indicating no contribution of GIGYF2 to the pathogenesis of PD.