Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cells
Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cells
批准号:
21790927
负责人:
KATSUMOTO Takuo
金额:
$2.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
In this study, we mainly analyzed the roles of MORF or MOZ in self-renewal of hematopoietic stem cells. High expression of MORF gene was appeared in hematopoietic stem cell fraction. Hematopoietic stem cell fractions were evenly decreased in aged and 5-FU treated MORF deficient mouse or in MOZ/MORF double heterozygous mouse. MORF was associated with AML1, PU.1 or GATA-1/2 and regulated their transcription. These results suggested MORF and MOZ modulated self-renewal activity of hematopoietic stem cells to interact with AML1, PU.1 or GATA-1/2 and to regulate their transcription activity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yukiko Aikawa1, Takuo Katsumoto1, Daniel G Tenen, Issay Kitabayashi1]
通讯作者:
Issay Kitabayashi1
Roles of histone acetyltransferase MORF and MOZ in hematopoiesis
组蛋白乙酰转移酶 MORF 和 MOZ 在造血中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Katsumoto, et al.]
通讯作者:
et al.
Histone acetyltransferase MOZ and MORF are essential for self-renewal of hematopoietic stem cells
组蛋白乙酰转移酶 MOZ 和 MORF 对于造血干细胞的自我更新至关重要
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[嶋晴子, 山中久美子, 相川祐規子, 勝本拓夫, 篠美花, 古関明彦, 北林一生, T.Katsumoto, 勝本拓夫]
通讯作者:
勝本拓夫
Roles of Ring1A/B and ROS in stem cell potential of MOZ and other myeloid leukemia
Ring1A/B 和 ROS 在 MOZ 和其他髓系白血病干细胞潜能中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yukiko Aikawa, Takuo Katsumoto, Haruko Shima]
通讯作者:
Haruko Shima
MOZは、MOZ/MLL融合遺伝子による白血病細胞化に必須である
MOZ/MLL 融合基因对于白血病细胞的形成至关重要
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[勝本拓夫, 相川祐規子, 北林一生]
通讯作者:
北林一生
共 8 条
Analysis of acute myeloid leukemia development mechanisms induced by MOZ/MLL fusion genes
-
批准号:23791094
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2011
-
负责人:KATSUMOTO Takuo
-
依托单位:
海外基金