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Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cells

Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cells
白血病相关因子MOZ和MORF在造血干细胞自我更新中的作用
批准号:
21790927
负责人:
KATSUMOTO Takuo
金额:
$2.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
In this study, we mainly analyzed the roles of MORF or MOZ in self-renewal of hematopoietic stem cells. High expression of MORF gene was appeared in hematopoietic stem cell fraction. Hematopoietic stem cell fractions were evenly decreased in aged and 5-FU treated MORF deficient mouse or in MOZ/MORF double heterozygous mouse. MORF was associated with AML1, PU.1 or GATA-1/2 and regulated their transcription. These results suggested MORF and MOZ modulated self-renewal activity of hematopoietic stem cells to interact with AML1, PU.1 or GATA-1/2 and to regulate their transcription activity.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yukiko Aikawa1, Takuo Katsumoto1, Daniel G Tenen, Issay Kitabayashi1]
通讯作者: Issay Kitabayashi1
Roles of histone acetyltransferase MORF and MOZ in hematopoiesis
组蛋白乙酰转移酶 MORF 和 MOZ 在造血中的作用
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Katsumoto, et al.]
通讯作者: et al.
Histone acetyltransferase MOZ and MORF are essential for self-renewal of hematopoietic stem cells
组蛋白乙酰转移酶 MOZ 和 MORF 对于造血干细胞的自我更新至关重要
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [嶋晴子, 山中久美子, 相川祐規子, 勝本拓夫, 篠美花, 古関明彦, 北林一生, T.Katsumoto, 勝本拓夫]
通讯作者: 勝本拓夫
Roles of Ring1A/B and ROS in stem cell potential of MOZ and other myeloid leukemia
Ring1A/B 和 ROS 在 MOZ 和其他髓系白血病干细胞潜能中的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yukiko Aikawa, Takuo Katsumoto, Haruko Shima]
通讯作者: Haruko Shima
8
    Analysis of acute myeloid leukemia development mechanisms induced by MOZ/MLL fusion genes
    • 批准号:
      23791094
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2011
    • 负责人:
      KATSUMOTO Takuo
    • 依托单位:
    海外基金