Mechanism of oral tolerance controlled by a novel regulatory T cell subset associated with a T cell anergy inducing gene

调节性T细胞（Tcells）参与维持免疫自身耐受。IL-10在维持机体正常免疫状态中具有重要作用。然而，由于缺乏其特异性标志物，很难评估分泌IL-10的T细胞的体内生理功能。最近，我们报道了分泌IL-10的T细胞是一种表达淋巴细胞活化基因-3（LAG-3）的CD 4 ^+ CD 25 ^-Foxp 3 ^-T细胞，这种新的CD 4 ^+ CD 25 ^-LAG 3 ^+ T细胞（LAG 3 T细胞）表达无反应性相关转录因子Egr 2，Egr 2可使CD 4 ^+ T细胞表达Blimp-1、IL-10和LAG 3。在这项研究中，我们证实了以抗原特异性方式控制LAG 3 Treg诱导的因素。这些发现可能导致新的抗原特异性治疗自身免疫性疾病。

Regulatory T cells(Tregs)are engaged in the maintenance of immunological self-tolerance. IL-10 has an important role in maintaining the normal immune state. However, it is difficult to assess the in vivo physiological function of IL-10-secreting Tregs because of the lack of its specific markers. Recently, we reported that IL-10-secreting Tregs can be delineated as CD4^+CD25^-Foxp3^-Tcells that characteristically express lymphocyte activation gene-3(LAG-3).Moreover, this novel CD4^+CD25^-LAG3^+Tregs(LAG3 Tregs)express anergy associated transcription factor Egr2, which confers Blimp-1, IL-10 and LAG3 expression of CD4^+Tcells. In this study, we confirmed the factors controlling LAG3 Treg-induction in an antigen specific manner. These findings could lead to the novel antigen-specific therapy for autoimmune diseases.