Tissue-specific roles of inositol 1,4,5-trisphosphate receptors for cardiovascular development

肌醇 1,4,5-三磷酸受体对心血管发育的组织特异性作用

• 批准号: 21791004
• 负责人: UCHIDA Keiko
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791004/
• 关键词: 発生; 循環器; シグナル伝達; 発生・分化; 再生医学; 循環器・高血圧; 動物

We previously showed that inositol 1, 4, 5-trisphosphate receptor (IP3R) 1 and 3 double knockout (1/3DKO) mice exhibited the defect of cardiovascular development. Our results from the marker analyses and the generation of tissue-specific 1/3DKO mice suggested that IP3R1 and 3 do not function in the subpopulation of the second heart field originated from Tbx1 expressed cells during heart development, and that IP3R1 and 3 in the endothelial cells may play redundant roles for the angiogenesis during embryonic vascular development.

我们以前研究发现，1，4，5-三磷酸肌醇受体（IP 3R）1和3双敲除（1/3DKO）小鼠表现出心血管发育缺陷。标记物分析和组织特异性1/3DKO小鼠的产生结果表明，在心脏发育过程中，IP 3R 1和3在来源于Tbx 1表达细胞的第二心脏区域亚群中不起作用，并且在内皮细胞中的IP 3R 1和3可能在胚胎血管发育过程中的血管生成中起冗余作用。

项目成果

Molecular embryology for an understanding of congenital heart diseases

• DOI: 10.1007/s12565-009-0023-4
• 发表时间: 2009-09-01
• 期刊: ANATOMICAL SCIENCE INTERNATIONAL
• 影响因子: 1.2
• 作者: Yamagishi, Hiroyuki;Maeda, Jun;Yamagishi, Chihiro
• 通讯作者: Yamagishi, Chihiro

Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

• DOI: 10.1371/journal.pone.0012500
• 发表时间: 2010-09
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: K. Uchida;Megumi Aramaki;Maki Nakazawa;Chihiro Yamagishi;S. Makino;K. Fukuda;Takeshi Nakamura;Takao Takahashi;K. Mikoshiba;H. Yamagishi

Type 1 and 3 Inositol 1,4,5-Trisphosphate Receptors in the Endotheliumare Required for Angiogenesis during Embryonic Vascular Development

内皮细胞中的 1 型和 3 型肌醇 1,4,5-三磷酸受体是胚胎血管发育过程中血管生成所必需的

• 发表时间: 2010
• 作者: Yamagishi H;Maeda J;Uchida K;Tsuchihashi T;Nakazawa M;Aramaki M;Kodo K;Yamagishi C.;内田敬子
• 通讯作者: 内田敬子

Type 1 and 3 Inositol 1,4,5-Trisphosphate Receptors in the Endothelium are Required for Angiogenesis during Embryonic Vascular Development

内皮细胞中的 1 型和 3 型肌醇 1,4,5-三磷酸受体是胚胎血管发育过程中血管生成所必需的

• 发表时间: 2010
• 作者: Yamagishi H;Maeda J;Uchida K;Tsuchihashi T;Nakazawa M;Aramaki M;Kodo K;Yamagishi C.;内田敬子;内田敬子
• 通讯作者: 内田敬子

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