Tissue-specific roles of inositol 1,4,5-trisphosphate receptors for cardiovascular development

我们以前研究发现，1，4，5-三磷酸肌醇受体（IP 3R）1和3双敲除（1/3DKO）小鼠表现出心血管发育缺陷。标记物分析和组织特异性1/3DKO小鼠的产生结果表明，在心脏发育过程中，IP 3R 1和3在来源于Tbx 1表达细胞的第二心脏区域亚群中不起作用，并且在内皮细胞中的IP 3R 1和3可能在胚胎血管发育过程中的血管生成中起冗余作用。

We previously showed that inositol 1, 4, 5-trisphosphate receptor (IP3R) 1 and 3 double knockout (1/3DKO) mice exhibited the defect of cardiovascular development. Our results from the marker analyses and the generation of tissue-specific 1/3DKO mice suggested that IP3R1 and 3 do not function in the subpopulation of the second heart field originated from Tbx1 expressed cells during heart development, and that IP3R1 and 3 in the endothelial cells may play redundant roles for the angiogenesis during embryonic vascular development.