Elucidated of environmental and genetic effects on the neural network disorders.

在这项研究中，我们阐明了环境和遗传线索对神经网络形成的影响。首先，为了阐明环境应激的反应，采用神经前体细胞进行分析。这些对神经前体细胞的作用及相关信号转录明显促进了细胞周期和神经元伸展形态的恢复。它可能与神经前体细胞的生存反应有关，神经前体细胞表达神经生长因子受体，并与几种环境线索有关。有趣的是，神经元损伤的成年大鼠脑内表现出类似的形态变化，在非兴奋性条件下，这种变化促进了突触前膜和突触后膜的自分泌样和双分泌样样的形成。

In this study, we elucidated the effects of environmental and genetic cues for the neural network formations. First, to clarify the response of environmental stress were analyzed using neuronal progenitor cells. Those effects and related signal transcription on neuro-progenitor cells were clearly promoted rescue on cell cycle and neuronal stretched shapes. It may have been involving survival response in neuro progenitor cell that was expressing the receptor of neuronal growth factors and that shown responsible for several environment cues. Interestingly, neuronal injured adult rat brain indicated similar morphological alteration that has promoted the autocrine-like and diacrine-like formation at pre- and post- synaptic membrane during a non-excitable condition.