Does maternal immune activation negatively affect fetal brain neuronal development?

母体免疫激活会对胎儿大脑神经元发育产生负面影响吗？

• 批准号: 21791050
• 负责人: OH-NISHI Arata
• 金额: $ 2.66万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791050/
• 关键词: インフルエンザ感染; 妊娠; 胎児脳神経発達; 海馬; シナプス; サイトカイン; ケモカイン; 免疫

Influence of maternal immune activation on neurodevelopment of fetal brain is not well understood. We investigated that influence of maternal immune activation by stranded RNA polyriboinosinic-polyribocytidilic acid administration on hippocampal pathology and synaptic function in juvenile offspring. In hippocampal CA1 region from juvenile offspring of Poly I:C treated dams, presynaptic fiver volley amplitude and field excitatory post synaptic potential slope were significant lower than control rats. In addition, short synaptic plasticity namely paired pulse facilitation ratio was significant higher and long-term potentiation impaired in hippocampal CA1 region from juvenile offspring of poly IC treated dams. In contrast, there were no effects in the hippocampal histology and neuronal nuclears antigen positive cell number from postnatal offspring of poly IC treated dams. Maternal immune activation causes of hippocampal synaptic dysfunction but not neuronal loss in the postnatal periods.

母体免疫激活对胎儿脑神经发育的影响尚不清楚。我们研究了单链RNA多聚核糖肌苷酸-多聚核糖胞苷酸给药后母体免疫激活对幼年子代海马病理和突触功能的影响。Poly I：C处理组幼年子代海马CA 1区突触前肝齐射幅度和场兴奋性突触后电位斜率均显著低于对照组。此外，短突触可塑性，即配对脉冲易化率显着较高，长时程增强受损，海马CA 1区从青少年后代的聚IC处理的母鼠。与此相反，在海马组织学和神经元核抗原阳性细胞数从出生后后代的聚IC处理的母鼠没有影响。母体免疫激活导致海马突触功能障碍，但不是出生后神经元丢失。

项目成果

Reduction of dopmamine D2 receptor binding in medial prefrontal cortex in schizophrenia animal model with maternal immune activation.

母体免疫激活的精神分裂症动物模型中内侧前额叶皮层多巴胺 D2 受体结合的减少。

• 发表时间: 2010
• 作者: Arata Oh-Nish;Yuji Nagai;Tetsuya Suhara;Shigeru Obayashi
• 通讯作者: Shigeru Obayashi

Influence of maternal immune activation in embryonic stage on hippocampal function in juvenile stage

胚胎期母体免疫激活对幼年期海马功能的影响

• 发表时间: 2009
• 作者: Arata Oh-Nishi;Izumi Sugihara;Tetsuya Suhara;Shigeru Obayashi.
• 通讯作者: Shigeru Obayashi.

Integrated approach of various discipline for understanding developmental psychiatric disorders

理解发育性精神障碍的不同学科的综合方法

• 发表时间: 2010
• 作者: A.Oh-Nishi;S.Obayashi;I.Sugihara;T.Minamimoto;T.Suhara.;Arata Oh-Nishi
• 通讯作者: Arata Oh-Nishi

Reduction of C11-FLB 457 (dopamine D2 receptor ligand) binding in medial prefrontal cortex in mature rat with maternal immune activation.

母体免疫激活的成熟大鼠内侧前额皮质中 C11-FLB 457（多巴胺 D2 受体配体）的结合减少。

• 发表时间: 2010
• 作者: A.Oh-Nishi;Y.Nagai;T.Suhara;S.Obayashi
• 通讯作者: S.Obayashi

幼若期海馬機能に対する胎生期母体免疫活性の影響

胎儿母体免疫激活对幼年海马功能的影响

• 发表时间: 2009
• 作者: Arata Oh-Nish;Yuji Nagai;Tetsuya Suhara;Shigeru Obayashi;大西新
• 通讯作者: 大西新