Dopamine D2 receptor dysfunction in the extra-striatal region in maternal immune activation rodent model

母体免疫激活啮齿动物模型纹状体外区多巴胺 D2 受体功能障碍

• 批准号: 23700432
• 负责人: OH-NISHI Arata
• 金额: $ 2.83万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700432/
• 关键词: 統合失調症; ドーパミン受容体; PET; ドーパミン; ドーパミンD2受容体; 発達障害; 妊娠; 免疫; 精神疾患

We investigated D2Rs radio-ligand such as 11C-FLB457 binding potential in the whole brain of maternal immune activation (MIA) rat model with schizophrenia by micro-PET. We found that statistic of 11C-FLB457 binding potential in the anterior cingulate cortex (ACC) of MIA rat model was much lower than another extra-striatal regions by micro-PET. In the ACC, both mature dopamine D2 receptor protein expression and parvalbumin (PV) positive interneurons were also decreased. Our finding of MIA model was in agreement with some of previously both PET and postmortem studies with schizophrenia patients. Hence, Our finding of MIA model strongly raise the possibility that D2R and interneuronal alteration in the ACC are one of the important pathology in schizophrenia.

我们研究了Micro-pet的精神分裂症，研究了母体免疫激活（MIA）大鼠模型的整个大脑中的D2RS无线电配体，例如11C-FLB457的结合潜力。我们发现，在MIA大鼠模型的前扣带回皮层（ACC）中，11C-FLB457结合电位的统计量远低于Micro-pet的另一个纹状体外区域。在ACC中，成熟的多巴胺D2受体蛋白表达和白蛋白（PV）阳性神经元也均降低。我们对MIA模型的发现与精神分裂症患者的一些以前的PET和死后研究一致。因此，我们对MIA模型的发现强烈提高了ACC中D2R和神经元改变是精神分裂症的重要病理之一。

项目成果

統合失調症モデル動物： Maternal immune activation model rat における線条体外のドーパミンD2受容体機能障害の解析

精神分裂症模型动物：母体免疫激活模型大鼠纹状体外多巴胺D2受体功能障碍分析

• 发表时间: 2012
• 作者: 大西新;永井裕司;南本敬史;須原哲也;大西新
• 通讯作者: 大西新

A biological homology between a rodent model of maternal immune activation and schizophrenia patients: A comparative study using positron emission tomography and immune histochemistry

母体免疫激活的啮齿动物模型与精神分裂症患者之间的生物同源性：使用正电子发射断层扫描和免疫组织化学的比较研究

• 发表时间: 2011
• 作者: Arata Oh-Nishi;Yuji Nagai;Takafumi Minamimoto;Tetsuya Suhara
• 通讯作者: Tetsuya Suhara

Neuronal dysfunction in cingulate area in maternal immune activation rodent model of schizophrenia.

精神分裂症母体免疫激活啮齿动物模型扣带区神经元功能障碍。

• 作者: Arata Oh-Nishi;Yuji Nagai;Takafumi Minamimoto;Tetsuya Suhara.
• 通讯作者: Tetsuya Suhara.

Molecular imaging for motivational function and dysfunction

动机功能和功能障碍的分子成像

• 发表时间: 2011
• 作者: Takafumi Minamimoto;Yukiko Hori;Yuji Nagai;Arata Oh-Nishi;Tetsuya Suhar
• 通讯作者: Tetsuya Suhar

Maternal immune activation leads to schizophreniform pathology in rodent offspring :Elucidating a non-inherited schizophrenia onset mechanism

母体免疫激活导致啮齿动物后代出现精神分裂症病理：阐明非遗传性精神分裂症发病机制

• 发表时间: 2011
• 作者: Arata Oh-Nishi;Yuji Nagai;Takafumi Minamimoto;Tetsuya Suhara
• 通讯作者: Tetsuya Suhara