Dopamine D2 receptor dysfunction in the extra-striatal region in maternal immune activation rodent model

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We investigated D2Rs radio-ligand such as 11C-FLB457 binding potential in the whole brain of maternal immune activation (MIA) rat model with schizophrenia by micro-PET. We found that statistic of 11C-FLB457 binding potential in the anterior cingulate cortex (ACC) of MIA rat model was much lower than another extra-striatal regions by micro-PET. In the ACC, both mature dopamine D2 receptor protein expression and parvalbumin (PV) positive interneurons were also decreased. Our finding of MIA model was in agreement with some of previously both PET and postmortem studies with schizophrenia patients. Hence, Our finding of MIA model strongly raise the possibility that D2R and interneuronal alteration in the ACC are one of the important pathology in schizophrenia.