Development of therapeutic strategies for periventricular leukomalacia based on the activation of microglia and the inhibition of inflammatory mediatior.

虽然脑室周围白质软化症（PVL）是早产儿最常见的脑损伤之一，但一直没有有效的治疗方法。我们研究了PVL与小胶质细胞关系的机制。我们发现，造血前列腺素D合成酶和微粒体前列腺素E合成酶上调的胶质细胞在婴儿大脑的白色物质缺氧/缺血（H/I）的侮辱母亲感染。我们认为，这些胡萝卜素可能通过激活小胶质细胞增加PVL的风险。

Although periventricular leukomalacia (PVL) is one of the most common brain injuries in premature infants, there has been no effective treatment. We investigated the mechanism of PVL in relationship to microglia. We found that hematopoietic prostaglandin D synthase and microsomal prostaglandin E synthase were upregulated in glial cytoplasms in white matter of infant brains during hypoxic/ischemic (H/I) insults following maternal infection. We suggest that these prostaglandins may elevated the risk of PVL via microglial activation.