Investments of regenerative medicine for epidermolysis bullosa using bone marrow stem cells

利用骨髓干细胞治疗大疱性表皮松解症的再生医学投资

• 批准号: 21791052
• 负责人: INOKUMA Daisuke
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791052/
• 关键词: 皮膚炎症; 再生学

Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments to achieve radical cure for congenital disorder, to which there is no effective therapy, have been done.In our study, first as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa.

最近的研究表明，骨髓细胞转分化为各种细胞谱系，包括皮肤。为了根治目前尚无有效治疗方法的先天性疾病，已经进行了大量的投资。本研究首先作为基础研究，证明了从骨髓来源的细胞向角质形成细胞转分化的角质形成细胞分泌因子的存在。接下来，作为临床前步骤，将正常小鼠的骨髓移植到大疱性表皮病模型小鼠之一的XVII型胶原基因敲除小鼠中，诱导缺陷蛋白（XVII型胶原）的产生并改善小鼠的临床表现。提示正常小鼠骨髓移植是治疗大疱性表皮病的有效方法之一。

项目成果

骨髄幹細胞を用いた表皮水疱症における再生医療

利用骨髓干细胞治疗大疱性表皮松解症的再生医学

• 发表时间: 2010
• 作者: 猪熊大輔;阿部理一郎;清水宏
• 通讯作者: 清水宏

Scleredema adultorum associated with sarcoidosis

与结节病相关的成人硬肿

• 期刊: Clin Exp Dermatol (in press)
• 作者: Inokuma D;Sawamura D;Shibaki A;Abe R;Shimizu H.
• 通讯作者: Shimizu H.

血漿交換が奏効した中毒性表皮壊死症の1例皮膚科の臨床

皮肤科采用血浆置换成功治疗中毒性表皮坏死松解症的临床病例。

• 发表时间: 2011
• 期刊: 53
• 作者: 馬場慶子;阿部理一郎;飯谷麻里;猪熊大輔;三浦正義;安藤佐土美;松村和子; 清水宏
• 通讯作者: 清水宏

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Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice

• DOI: 10.1073/pnas.1000044107
• 发表时间: 2010-08-10
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Fujita, Yasuyuki;Abe, Riichiro;Shimizu, Hiroshi
• 通讯作者: Shimizu, Hiroshi