Pathomechanism of lupus erythematosus

通过制造具有肥大细胞缺陷的狼疮模型小鼠，评价肥大细胞在狼疮模型小鼠皮肤损伤中的作用。MRL/lpr小鼠与Kit^<W-sh>(W^<sh>)小鼠杂交7次，得到无肥大细胞的纯合子W^<sh>。纯合子W^<sh>中出现狼疮样病变的比例为42%，而杂合子W^<sh>中出现狼疮样病变的比例为33%。即使肥大细胞缺失，纯合子W^<sh>和MRL/lpr均可见皮肤病变。我们现在正在研究肥大细胞在纯合子W^<sh>和杂合子W^<sh>皮肤病变中的作用。

The role of mast cells was assessed in the skin lesions of lupus model mouse by making a new model mouse which defects mast cells. MRL/lpr mice were mated with Kit^<W-sh>(W^<sh>) mice 7 times and homozygous W^<sh> which is absent of mast cells, was made. Lupus like lesion was seen 42% in homozygous W^<sh>, on the other hand, such skin lesions were seen 33% in heterozygous W^<sh>. Even if mast cells were absent, skin lesion was seen in homozygous W^<sh> as well as MRL/lpr skin lesion. We are now investigating the role of mast cells in skin lesions of homozygous W^<sh> and heterozygous W^<sh>.