Pathomechanism of lupus erythematosus

红斑狼疮的发病机制

• 批准号: 21791088
• 负责人: YOSHIMASU Takashi
• 金额: $ 2.75万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791088/
• 关键词: ループスエリテマトーデス; 肥満細胞; モデルマウス; エリテマトーデス; ヒスタミンレセプター

The role of mast cells was assessed in the skin lesions of lupus model mouse by making a new model mouse which defects mast cells. MRL/lpr mice were mated with Kit^<W-sh>(W^<sh>) mice 7 times and homozygous W^<sh> which is absent of mast cells, was made. Lupus like lesion was seen 42% in homozygous W^<sh>, on the other hand, such skin lesions were seen 33% in heterozygous W^<sh>. Even if mast cells were absent, skin lesion was seen in homozygous W^<sh> as well as MRL/lpr skin lesion. We are now investigating the role of mast cells in skin lesions of homozygous W^<sh> and heterozygous W^<sh>.

通过制作一种新的肥大细胞缺陷性狼疮小鼠模型，评价肥大细胞在狼疮模型小鼠皮肤病变中的作用。将MRL/LPR小鼠与Kit^&lt；W-sh&gt；(W^&lt；sh&gt；)小鼠交配7次，得到纯合子W^&lt；sh&gt；狼疮样皮损在纯合子W^&lt；sh&gt；中占42%，在杂合子W^&lt；sh&gt；中占33%。即使没有肥大细胞，在纯合子W^&lt；sh&gt；和MRL/LPR皮损中也可以看到皮损。我们现在正在研究肥大细胞在纯合子W^&lt；sh&gt；和杂合子W^&lt；sh&gt；皮损中的作用。

项目成果

The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice

紫外线A1照射对MRL/lpr小鼠自发性红斑狼疮样皮损的保护作用

• 发表时间: 2009
• 期刊: Clinical and developmental Immunology 673952.Epub
• 作者: Naoya Mikita;Nobuo Kanazawa;Takashi Yoshimasu;et al
• 通讯作者: et al

急性蕁麻疹とHelicobacter Pylori(H.pylori)感染症との関連について.

关于急性荨麻疹与幽门螺杆菌（H. pylori）感染的关系。

• 发表时间: 2009
• 作者: 吉益隆;古川福実;吉益隆;吉益隆
• 通讯作者: 吉益隆

A mutation of LIPH gene in Japanese siblings with woolly hair

日本羊毛兄弟姐妹的LIPH基因突变

• 发表时间: 2010
• 作者: Takashi Yoshimasu;Nobuo Kanazawa;Fukumi Furukawa;Mari Wada
• 通讯作者: Mari Wada

湿疹・皮膚炎群に対するルリクールVG軟膏の有用性に関する検討

Luricool VG软膏对湿疹/皮炎人群的有效性研究

• 发表时间: 2010
• 期刊: 新薬と臨床 59
• 作者: 吉益隆;古川福実
• 通讯作者: 古川福実

IgE bearing cells are involved in alopecia areata irrespecitve of history of atopic dermatitis

无论是否有特应性皮炎病史，IgE 携带细胞都与斑秃有关

• 发表时间: 2010
• 作者: Takashi Yoshimasu;Nobuo Kanazawa;Fukumi Furukawa
• 通讯作者: Fukumi Furukawa