Development of a New Model for Atopic Dermatitis Using Filaggrin Mutant Mice

为了更好地了解聚丝蛋白的功能特性，并为阐明特应性皮炎的发病机制建立新的模型，我们利用聚丝蛋白突变且表达显著降低的片状尾小鼠。本研究显示片状尾小鼠从外到内的渗透性增强，但表明聚丝蛋白缺乏本身不受经皮失水增加的影响。与野生型小鼠相比，片状尾小鼠的经皮免疫反应增强。

To better understand the functional properties of filaggrin and to develop a new model for elucidating the pathogenesis of atopic dermatitis, flaky tail mice, which have mutant filaggrin and its expression is significantly reduced, were utilized. This study exhibited enhanced outside-to-inside permeability in flaky tail mice, however it indicated filaggrin deficiency itself was not affected with increased transepidermal water loss. Flaky tail mice showed enhanced percutaneous immune response, as compared with wild-type mice.