IL-12-mediated regulation of human chemokine receptor function

IL-12 介导的人趋化因子受体功能调节

• 批准号: 14570405
• 负责人: KAWASAKI Hiroshi
• 金额: $ 1.92万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570405/
• 关键词: cytokine; chemokine; dendritic cell; signal transduction; antigen presentation; allergy; infalmmation; autoimmunity; 自己免疫疾患

To clarify the mechanism of the initiation of an Ag-specific immune response in epidermis in the human system, we examined the role of the interplay between dendritic cells (DCs) and Langerhans cells (LCs) in vitro. DCs exhibited more potent expressions of the MHC product and costimulatory molecules than LCs. LCs were less effective for the internalization of exogenous Ag, and the activation of allogeneic and autologous Ag-specific T cells than DCs. DCs and LCs expressed different in chemokine receptor repertoire and responsiveness. LCs can transfer unprocessed Ag to DCs via cell to cell contact, and these trans-Ag-loaded DCs induced an Ag-specific T cell response

为了阐明人类系统中表皮中Ag特异性免疫应答的启动机制，我们研究了树突状细胞（DC）和朗格汉斯细胞（LC）之间的相互作用。DC表现出更有效的表达MHC产物和共刺激分子比LC。与DC相比，LC对外源性Ag的内化以及同种异体和自体Ag特异性T细胞的活化效果较差。DC和LC在趋化因子受体库和反应性方面存在差异。LC可以通过细胞与细胞的接触将未加工的Ag转移到DC，这些载Ag的DC诱导了Ag特异性T细胞应答

项目成果

Ohnuma K, et al.: "G1/S cell cycle arrest provoked in human T cells by antibody to CD26"Immunology. 107(3). 325-333 (2002)

Ohnuma K 等人：“CD26 抗体在人 T 细胞中引发 G1/S 细胞周期停滞”免疫学。

Miyake-Nishijima, R et al.: "Role of Crk-associated substrate lymphocyte rype in pathophysiology of rheumatid Arthitis in Tax transgenic mice and human"Athritis and Rhematism. 48・7. 1890-1900 (2003)

Miyake-Nishijima, R 等人：“Crk 相关底物淋巴细胞类型在 Tax 转基因小鼠和人类类风湿性关节炎病理生理学中的作用”关节炎和风湿病 1890-1900 (2003)。

Iwata S: "Distinctive Signaling Pathways Through CD82 and Beta 1 Intergrins In Human T Cells"European Journal of Immunology. 32(5). 1328-1337 (2002)

Iwata S：“人类 T 细胞中通过 CD82 和 Beta 1 整合素的独特信号传导途径”欧洲免疫学杂志。

Iwata, S et al.: "Distinctive signaling pathway through CD82 and betal Integrins in human T cells"European Journal of Immunology. 32・5. 1328-1337 (2002)

Iwata, S 等人：“人类 T 细胞中通过 CD82 和 β 整合素的独特信号传导途径”欧洲免疫学杂志 32·5 (2002)。

Kobayashi, H et al.: "Reduction of serum soluble CD26 and its correlation of disease activity in Systemic Lupus Erythematosus"Journal of Rheumatology. 29・9. 1858-1866 (2002)

Kobayashi, H 等：“系统性红斑狼疮中血清可溶性 CD26 的减少及其与疾病活动的相关性”风湿病学杂志 29·9 (2002)。