VLDLR overexpression rat : evaluation as an animal model of autism

VLDLR过度表达大鼠：作为自闭症动物模型的评估

• 批准号: 21791126
• 负责人: IWATA Keiko
• 金额: $ 2.83万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791126/
• 关键词: 児童; 思春期精神医学; 自閉症; ラット; VLDLR; Reelin

It has been reported that level of VLDLR mRNA was increased in post mortem studies of autistic brain. In this study, we generated transgenic (Tg) rats overexpressing VLDLR and examined its histological and behavioral features. Results indicated that the spontaneous locomotor activity in Tg rats was significantly increased without detectable changes in histology. Additionally, Tg rats tended to show performance deficits in radial maze, suggesting that spatial working memory was slightly impaired. These results suggest that VLDLR level might be involved in locomotor activity and memory function. Patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberration. Therefore, it is significant for the clinical aspect that these behavioral phenotypes were detected without neuroanatomical abnormality in VLDLR Tg rats.

已有研究表明，自闭症患者死后脑组织中VLDLR mRNA水平升高。在这项研究中，我们产生了转基因（Tg）大鼠过表达VLDLR，并检查其组织学和行为学特征。结果表明，转基因大鼠的自发运动活动显着增加，组织学无明显变化。此外，Tg大鼠在径向迷宫中倾向于表现出性能缺陷，表明空间工作记忆轻微受损。这些结果提示VLDLR水平可能与运动活动和记忆功能有关。患有神经发育或精神疾病的患者没有表现出显著的神经解剖学畸变。因此，在VLDLR Tg大鼠中检测到这些行为表型而没有神经解剖学异常对于临床方面是有意义的。

项目成果

Novel Events in Mitchondria : Increase of Poly(ADP-ribosyl)ation in Human Promyelocytic Leukemia HL-60 Cell Line during Differentiation by Nicotinamide.

线粒体中的新事件：烟酰胺分化过程中人早幼粒细胞白血病 HL-60 细胞系中聚（ADP-核糖基）化的增加。

• 发表时间: 2010
• 期刊: Process Biochemistry 45
• 作者: Iwata;K.;Ogata;S.;Taguchi;H.
• 通讯作者: H.

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• 发表时间: 2010

VLDLR overexpression rat: evaluation as an animal model of autism.

VLDLR 过度表达大鼠：作为自闭症动物模型的评估。

• 发表时间: 2010
• 作者: Iwata K;Matsuzaki H;Izumo N;Ichitani Y;Mori N.
• 通讯作者: Mori N.