Analysis of mechanisms and functions in Ca2+ response regulated by methamphetamine and morphine on drug dependence
Analysis of mechanisms and functions in Ca2+ response regulated by methamphetamine and morphine on drug dependence
批准号:
21791153
负责人:
SHIBASAKI Masahiro
金额:
$1.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Administration of nifedipine dose-dependently reduced the development of methamphetamine- and morphine-induced rewarding effect. Under the conditions, protein levels of L-type VDCC in the limbic forebrain were significantly increased on methamphetamine- and morphine-induced rewarding effects. The up-regulation was regulated by Vps34 relating intracellular vesicular traffic. Furthermore, enhancement of Ca2+ response by L-type VDCC induced increase of ADF and development of dependence on methamphetamine and morphine.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Up-regulation of Ca(v)1.2 subunit via facilitating trafficking incuced by Vps34 on morphine-induced place preference in mice.
通过促进 Vps34 诱导的运输来上调 Ca(v)1.2 亚基对吗啡诱导的小鼠位置偏好。
DOI:
--
发表时间:
2011
期刊:
Eur J Phamacol
影响因子:
--
作者:
[Shibasaki M, Kurokawa K, Mizuno K, Ohkuma S., Shibasaki M.]
通讯作者:
Shibasaki M.
Methamphetamine-induced up-regulation of alpha(2)/delta subunit of voltage-gated calcium channels is regulated by dopamine receptors
甲基苯丙胺诱导的电压门控钙通道α(2)/δ亚基上调受多巴胺受体调节
DOI:
--
发表时间:
2010
期刊:
Synapse
影响因子:
2.3
作者:
[Kurokawa K, Shibasaki M, Ohkuma S.]
通讯作者:
Ohkuma S.
Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization.
α2/δ亚基在吗啡诱导的奖赏效应和行为敏化的发展中的作用。
DOI:
--
发表时间:
2009
期刊:
Neuroscience. 163
影响因子:
--
作者:
[Shibasaki M, Kurokawa K, Ohkuma S.]
通讯作者:
Ohkuma S.
Methamphetamine 誘発精神依存形成における actin depolymerizing factor の関与
肌动蛋白解聚因子参与甲基苯丙胺诱导的精神依赖形成
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[芝崎真裕, 黒川和宏, 水野晃治, 大熊誠太郎]
通讯作者:
大熊誠太郎
エタノール身体依存におけるアクチン動態
物理乙醇依赖中的肌动蛋白动力学
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[芝崎真裕, 水野晃治, 黒川和宏, 大熊誠太郎]
通讯作者:
大熊誠太郎
共 25 条
Interaction between calcium dynamics and actin skeleton on methamphetamine-induced rewarding effects
-
批准号:23700453
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2011
-
负责人:SHIBASAKI Masahiro
-
依托单位:
海外基金