MR imaging of HER-2 in CNS tumors using Affibody

检测HER-2的表达具有临床意义，因为HER-2的表达情况不同，治疗方法和预后也不同。在这项研究中，我们重点研究了一种名为afficbody的小分子，它的分子大小是抗体的十分之一，具有相同的能力。SPIO标记在Affbody上进行MRI检测。将HER-2过表达肿瘤（SKOV-3卵巢癌细胞系）接种于SCID小鼠后，annexin - spio在MRI上成功成像HER-2受体。在组织学上证实了词缀和SPIO的积累。

Detecting HER-2 expression is clinically relevant, as treatment methods and prognosis differ according to HER-2 expression status. In this study, we have focused on a small molecule named Affibody, which is one-tenth in molecular size of an antibody, possessing equal capability. SPIO was labeled to Affbody for MRI detection. When HER-2 overexpressing tumor (SKOV-3 ovarian cancer cell line) was inoculated to a SCID mouse, Affibody-SPIO successfully imaged HER-2 receptor on MRI. Accumulation of Affibody and SPIO was confirmed on histology.