Mechanical analyses and treatment of immunodeficiency following burn injury

烧伤后免疫缺陷的力学分析和治疗

• 批准号: 22592027
• 负责人: KINOSHITA Manabu
• 金额: $ 2.91万
• 依托单位: National Defense Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592027/
• 关键词: 熱傷; 複合免疫不全; 好中球; クッパー細胞; 熱傷後感染; IL-18; CD68陽性クッパー細胞; CD11b陽性クッパー細胞; CD68陽性Kupffer細胞; CD11b陽性Kupffer細胞; 免疫不全; 活性酸素; マウス熱傷モデル; 細菌感染; NK細胞

Severely burn-injured hosts are known to be highly susceptible to bacterial infections/sepsis, and their outcomes become extremely poor due to infectious complications. Their host defense systems against infections, such as Th1-mediated cellular immunity, Th2-mediated humoral immunity and neutrophil-mediated immunity, are severely and multifactorially impaired. Multiple IL-18 injections can effectively restore these impaired immune responses in the immunocompromised mice receiving severe burn injury, thus improving their survival after bacterial infections. IL-18 therapy also restored burn injury-induced phenotypic alteration of Kupffer cells, namely increasing CD68+ Kupffer cells but decreasing CD11b+ Kupffer cells.

已知严重烧伤的宿主对细菌感染/脓毒症高度敏感，并且由于感染性并发症，其结果变得非常差。它们的宿主抗感染防御系统，如Th 1介导的细胞免疫、Th 2介导的体液免疫和嗜中性粒细胞介导的免疫，受到严重和多因素的损害。多次IL-18注射可以有效地恢复接受严重烧伤的免疫功能低下小鼠中这些受损的免疫应答，从而提高细菌感染后的存活率。IL-18治疗还恢复了烧伤诱导的枯否细胞表型改变，即增加CD 68+枯否细胞，但减少CD 11b+枯否细胞。

项目成果

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

• DOI: 10.1016/j.jhep.2010.04.037
• 发表时间: 2010-11-01
• 期刊: JOURNAL OF HEPATOLOGY
• 影响因子: 25.7
• 作者: Kinoshita, Manabu;Uchida, Takefumi;Seki, Shuhji
• 通讯作者: Seki, Shuhji

合成CRPのヒト末梢血単核球に対する炎症性サイトカイン産生抑制効果と抗腫瘍活性増強効果

合成CRP抑制炎症细胞因子的产生并增强人外周血单个核细胞的抗肿瘤活性

• 发表时间: 2013
• 期刊: 外科と代謝・栄養
• 作者: 佐藤 厚志;木下 学;中島弘幸;中島正裕;五十嵐正巳;関 修司
• 通讯作者: 関 修司

Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock

脂质体包裹的血红蛋白可减轻低血红蛋白休克期间的心功能障碍和交感神经活动

• 发表时间: 2012
• 期刊: SHOCK
• 影响因子: 3.1
• 作者: Nogami;Y.;Takase;B.;Kinoshita;M.;Shono;S.;Kaneda;S.;Tanaka;Y.;Kishimoto;S.;Hattori;H.;Ishihara;M
• 通讯作者: M

Neutralization of IL-10 restores the down-regulation of IL-18 receptor on NK cells and IFN-γ production in septic mice, thus leading to an improved survival

中和 IL-10 可恢复脓毒症小鼠 NK 细胞上 IL-18 受体的下调和 IFN-γ 的产生，从而提高生存率

• 发表时间: 2012
• 期刊: SHOCK
• 影响因子: 3.1
• 作者: Hiraki S;Ono S;Kinoshita M;Tsujimoto H;Takahata;R.;Miyazaki H.;Saitoh D;Seki S;Hase K
• 通讯作者: Hase K

Characteristic changes in heart rate variability induces during hemorrhagic shock, and effect of liposome-encapsulated hemoglobin in rats

失血性休克期间心率变异性的特征性变化以及脂质体包裹的血红蛋白对大鼠的影响

• 发表时间: 2010
• 期刊: J Arrhythmia
• 作者: Nogami;Y.;Takase;B.;Kinoshita;M.;Shono;S.;Kaneda;S.;Ishihara;M.;Kikuchi;M.;Maehara;T
• 通讯作者: T