Mechanical analyses and treatment of immunodeficiency following burn injury

众所周知，严重烧伤的宿主非常容易受到细菌感染/败血症的影响，由于感染并发症，他们的预后变得极其糟糕。它们的宿主防御系统，如Th1介导的细胞免疫、Th2介导的体液免疫和中性粒细胞介导的免疫，都受到严重和多因素的损害。多次注射IL-18可以有效地恢复严重烧伤后免疫低下小鼠的免疫反应，从而提高它们在细菌感染后的存活率。IL-18治疗还能恢复烧伤后Kupffer细胞的表型改变，即CD68+Kupffer细胞增加，CD11b+Kupffer细胞减少。

Severely burn-injured hosts are known to be highly susceptible to bacterial infections/sepsis, and their outcomes become extremely poor due to infectious complications. Their host defense systems against infections, such as Th1-mediated cellular immunity, Th2-mediated humoral immunity and neutrophil-mediated immunity, are severely and multifactorially impaired. Multiple IL-18 injections can effectively restore these impaired immune responses in the immunocompromised mice receiving severe burn injury, thus improving their survival after bacterial infections. IL-18 therapy also restored burn injury-induced phenotypic alteration of Kupffer cells, namely increasing CD68+ Kupffer cells but decreasing CD11b+ Kupffer cells.