Control of intracellular signaling, involved in neuronal differentiation by using protein transduction domain and its application

由于中枢神经系统不是自然再生的，因此通过移植神经干细胞有望使受损的脑/神经元再生。在这项研究中明确的主题是1；皮肤来源的前体细胞的神经分化潜能2；利用多肽控制参与神经分化的细胞内因子。我们鉴定了皮肤来源的前体细胞具有神经分化能力，并且细胞从分离到移植不需要进行基因操作。我设计的多肽，具有很小的细胞毒性，它的引入是为了控制神经元分化诱导因子参与的细胞内信号传导。皮源性前体细胞的利用被认为是当时再生医学的排他性规律。

As central nervous system is not regenerated naturally, reproduce of the damaged brain/neuron is expected by transplant of neuronal stem cells. Topics clarified in this study are 1 ; neuronal differentiation potential of skin-derived precursor cells 2 ; control of an intra-cellular factor involved in neuronal differentiation by using peptide. We identified the skin-derived precursor cells had neuronal differentiation ability and the advantage that there was no necessary of gene manipulation for the cells from isolation to transplant procedure. I designed the peptide, there was little cytotoxicity, which introduced to control intracellular signaling enrolled of neuronal differentiation inducing factor. It was thought that the utilization of the skin-derive precursor cells were useful as exclusive law of the regenerative medicine at this time