The antitumor effect of histone deacetylase inhibitor against multidrug-resistant Ewing' s sarcoma cells

组蛋白脱乙酰酶抑制剂对多重耐药尤文氏肉瘤细胞的抗肿瘤作用

• 批准号: 21791409
• 负责人: OKADA Takamitsu
• 金额: $ 1.66万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791409/
• 关键词: 多剤耐性因子; ピストン脱アセチル化酵素阻害剤; オートファジー; ユーイング肉腫; アポトーシス抵抗性; 多剤耐性; ヒストン脱アセチル化酵素阻; SAHA; Ewing肉腫; autophagic cell death; programed cell death type 2

We showed that histone deacetylase inhibitor SAHA induced apoptosis against parental drug-sensitive Ewing's sarcoma cells, however induced autophagic cell death against multidrug-resistant cells which was resistant to the apoptosic signals. Furthermore, we showed that SARA exhibited the antitumor effect against the animal model of multidrug-resistant Ewing's sarcoma.

我们发现，组蛋白去乙酰化酶抑制剂SAHA诱导对亲本药物敏感的尤文肉瘤细胞凋亡，但诱导自噬细胞死亡对多药耐药细胞，这是耐药信号。此外，我们表明，SARA对多药耐药尤文肉瘤的动物模型表现出抗肿瘤作用。