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The antitumor effect of histone deacetylase inhibitor against multidrug-resistant Ewing' s sarcoma cells

The antitumor effect of histone deacetylase inhibitor against multidrug-resistant Ewing' s sarcoma cells
组蛋白脱乙酰酶抑制剂对多重耐药尤文氏肉瘤细胞的抗肿瘤作用
批准号:
21791409
负责人:
OKADA Takamitsu
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
We showed that histone deacetylase inhibitor SAHA induced apoptosis against parental drug-sensitive Ewing's sarcoma cells, however induced autophagic cell death against multidrug-resistant cells which was resistant to the apoptosic signals. Furthermore, we showed that SARA exhibited the antitumor effect against the animal model of multidrug-resistant Ewing's sarcoma.
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The mechanisms of induction of autophagic cell death by histone deacetylase inhibitor SAHA
  • 批准号:
    23791660
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $1.58万
  • 财政年份:
    2011
  • 负责人:
    OKADA Takamitsu
  • 依托单位: