Analysis of function and the target genes of micro-RNAs in prostate cancer

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The mechanism of progression of cancer (PCa) to androgen-independent (AI) stage has not completely known. MicroRNAs (miRNAs) are known to have important roles in cancer development and malignant transformation. It is well known that miR-15a and miR-16-1 functions as tumor suppressor in lymphomas. We previously revealed that miR-15a caused growth inhibition and induced apoptosis in prostate cancer cells. In this study, we identified several miRNAs those were differentially expressed in PCa based on genome-wide miRNA expression signature. Analysis of the target genes may have therapeutic implications and may be exploited for future treatment of advanced PCa.