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Analysis of gene regulation networks controlled by microRNA in castration resistant prostate cancer

Analysis of gene regulation networks controlled by microRNA in castration resistant prostate cancer
去势抵抗性前列腺癌中 microRNA 控制的基因调控网络分析
批准号：
23592351
负责人：
KOJIMA Satoko
金额：
$3.41万
依托单位：
Teikyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592351/
关键词：
前立腺癌マイクロRNA標的遺伝子発現プロファイルゲノム増殖浸潤遺伝子解析発癌

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中文摘要
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英文摘要
Prostate cancer progress to castration resistant prostate cancer (CRPC) leading to the cancer death. Most of the patients who died with CRPC was initially revealed advanced disease with bone metastasis. We had analyzed the expression profiles of micro-RNAs in advanced prostate cancer. From 2011 to 2012, we confirmed the expression profile of microRNA of advanced prostate cancer. We had further analyzed the functions of down-regulated microRNAs in prostate cancer.a) miR-145 target FASN1 and controls proliferation, invasion and migration functions of prostate cancer. b) miR a and miR-133a target PNP and controls proliferation, invasion and migration functions of prostate cancer. c) miR-222 and miR-31 involved cancer pathway (by KEGG pathway). d) miR-143/145 forms cluster and target GOLM1 which affect proliferation, invasion and migration functions of prostate cancer.
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Identification of pureine nucleoside phosphorylase (PNP) as a novel target of tumor suppressors miR-1 and MiR-133a in prostate cancer
鉴定纯核苷磷酸化酶 (PNP) 作为前列腺癌肿瘤抑制因子 miR-1 和 MiR-133a 的新靶标
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Satoko Kojima, Takeshi Chiyomaru, Hirofumi Yoshino, Hideki Enokida, Nijiro Nohata, Miki Fuse, Tomohiko Ichikawa, Yukio Naya, Masayuki Nakagawa, and Naohiko Seki]
通讯作者： and Naohiko Seki
microRNAs detection in urine as diagnostic markers and predictors of recurrence of non-muscle invasive bladder cancer
尿液中 microRNA 检测作为非肌层浸润性膀胱癌复发的诊断标志物和预测因子
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [有田智洋, 市川大輔, 岡本和真　他, Enokida H]
通讯作者： Enokida H
Expression signature of tumor-suppressive miRNA and control of cancer associated molecular pathways in prostate cancer.
前列腺癌中肿瘤抑制 miRNA 的表达特征和癌症相关分子通路的控制。
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [5)Satoko Kojima, Hideki Enokida, Hirohumi Yoshino, Takeshi Chiyomaru, Takashi Kinoshita, Miki Fuse, Yukio Naya, Masayuki Nakagawa, Naohiko Seki]
通讯作者： Naohiko Seki
Identification of pureine nucleoside phosphorylase (PNP) as a novel target of tumor suppressors miR-1 and MiR-133a in prostate cancer.
鉴定纯核苷磷酸化酶 (PNP) 作为前列腺癌中肿瘤抑制因子 miR-1 和 MiR-133a 的新靶标。
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Satoko Kojima, Takeshi Chiyomaru, Hirofumi Yoshino, Hideki Enokida, Nijiro Nohata, Miki Fuse, Tomohiko Ichikawa, Yukio Naya, Masayuki Nakagawa, and Naohiko Seki]
通讯作者： and Naohiko Seki
共 14 条
    Usage and Writing Style of Kenji MIyazawa:The Acceptance of Standard Japanese in Tohoku Region during the Early Modern Era
    • 批准号：
      23520542
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.25万
    • 财政年份：
      2011
    • 负责人：
      KOJIMA Satoko
    • 依托单位：
      Iwate University
    Analysis of function and the target genes of micro-RNAs in prostate cancer
    • 批准号：
      21791530
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.75万
    • 财政年份：
      2009
    • 负责人：
      KOJIMA Satoko
    • 依托单位：
      Teikyo University
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