Functions of endometrial and circulating NK cells for achievement and maintenance of pregnancy

我使用妊娠和非妊娠外周血中的NK细胞和非妊娠的子宫内膜NK细胞来评估NK细胞在妊娠成功和维持妊娠中的作用。自然细胞毒性受体(NCRs)，尤其是NKp46在NK细胞上的异常表达与生殖功能障碍有关。生殖障碍患者存在NK细胞分泌细胞因子的异常。NK细胞表面NKp46的表达与NK细胞产生细胞因子有直接关系。

I evaluated the function of NK cells for achievement and maintenance of pregnancy using pregnant and non-pregnant peripheral blood NK cells and non-pregnant endometrial NK cells. The abnormal expression of natural cytotoxicity receptors (NCRs), especially NKp46 on NK cell is associated with reproductive failures. The abnormal cytokines production by NK cells exists in reproductive failures. There is a direct correlation between the expression of NKp46 on NK cell and cytokines production by NK cells.