Study on the chromosome aberration and infertility of an egg.
Study on the chromosome aberration and infertility of an egg.
批准号:
21791570
负责人:
YOSHIDA Kayo
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
分析哺乳动物减数分裂过程中染色体行为的机制对胎儿染色体畸变的发生具有重要意义。它也将有助于诊断和治疗。我们发现组蛋白H2AX基因参与了DNA损伤的修复,并分析了X射线对DNA损伤对胚胎早期发育的影响。此外,我们还建立了组蛋白H2AX基因敲除小鼠模型,并分析了其对DNA损伤的影响。
英文摘要
It is important to analyze the mechanisms of chromosome behavior in meiosis in mammals for chromosome aberrations in fetus. It will also contribute to diagnosis and treatment. We found that histone H2AX gene was involved in repair of DNA damages.We analyzed the effect of DNA damages by X-irradiation to early development of embryos. Furthermore, we made histone H2AX knock-out mouse and analyzed its effect after DNA damages.
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Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular iunctions.
损伤诱导的神经元内肽酶对于神经肌肉连接的突触前形成至关重要。
DOI:
--
发表时间:
2010
期刊:
J Neurosci.
影响因子:
--
作者:
[Nagata K., Kiryu-Seo S., Maeda M., Yoshida K., Morita T., Kiyama H.]
通讯作者:
Kiyama H.
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular iunctions
损伤诱导的神经元内肽酶对于神经肌肉连接的突触前形成至关重要
DOI:
--
发表时间:
2010
期刊:
J Neurosci. 30巻
影响因子:
--
作者:
[Nagata K., Kiryu-Seo S., Maeda M., Yoshida K., Morita T., Kiyama H.]
通讯作者:
Kiyama H.
Study on the Effect of Space Radiation to Mammalian ES and iPS Cells to Their Development
空间辐射对哺乳动物ES和iPS细胞发育影响的研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yoshida, K., Yoshida S., Egichi-kasai K., Morita T.]
通讯作者:
Morita T.
STUDY ON THE EFFECT OF SPACE RADIATION TO MANMMALIAN ES AND iPS CELLS TO THEIR DEVELOPMENT.
空间辐射对哺乳动物 ES 和 iPS 细胞发育影响的研究。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yoshida, K., Yoshida, S., Eguchi-kasai, K., Morita, T.]
通讯作者:
T.
Analysis of the genes which are involved in a spermatogenic defect in higher temperature in mouse
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批准号:25462572
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2013
-
负责人:YOSHIDA Kayo
-
依托单位:
Mental Health Support for Pregnant Women using Photovoice
-
批准号:23792650
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.91万
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财政年份:2011
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负责人:YOSHIDA Kayo
-
依托单位:
Study on infertility by chromosomal aberration
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批准号:19791159
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.32万
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财政年份:2007
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负责人:YOSHIDA Kayo
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依托单位:
海外基金