Basical study for regulation of apoptosis; Aiming to improve the results and to enlarge the application of cochlear implant surgery.

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Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are recently shown to have close relationship to the apoptosis. We demonstrated that uPAR was in the cochlea especially in organ of corti and spiral ganglion, which is indicating that the uPA-uPAR anti-apoptotic system is working in cochlea. Next we demonstrated, using cochlear organotypic cultures of the rat, that uPA attenuates the aminoglicoside induced apoptotic hair cell death in a dose dependent manner. We have also demonstrated that artificial anti-apototic protein PTD-FNK attenuates the aminoglicoside induced apoptotic hair cell death by affecting caspase-9 related mitochondrial apoptotic pathway.