Application of urokinase for inner ear therapy

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Urokinase is a drug used clinically as a thrombolytic agent. Recently, the anti-apoptotic effect of the urokinase has been reported. In this study, we have examined weather urokinase has the anti-apoptotic effect to the inner ear cells. We have shown that urokinase attenuated the inner ear hair cell death caused by aminoglicoside using the cochlear organotypic cultures. Expression of P38 could be seen in those who had given urokinase concomitantly with aminoglicoside, which suggested that urokinase showed antiapoptotic effect by activating the p38 MAPK pathway. We also showed that urokinase decreased the spiral ganglion cells death caused by gulutate. These result showed that urokinase could be one of a prommising drug for the inner ear therapy in future.