The immunosuppressive role of MDSC in microenvironment of head and neck cancer

骨髓源性抑制细胞（MDSC）是一个异质性细胞群，具有通过多种机制抑制免疫应答的潜能。用HLA-DR标记物检测肿瘤患者外周血中MDSC。本研究探讨了头颈部鳞状细胞癌（SCCHN）患者CD 14 +HLA-DR_2细胞的比例和特征。分选的CD 14 +HLA-DR_细胞能够有效地抑制抗CD 28刺激的T细胞的增殖和IFN-α的产生，表明CD 14 +HLA-DR_细胞作为有效的免疫抑制细胞，特别有助于SCCHN患者的肿瘤从宿主免疫系统逃逸。

Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.