The immunosuppressive role of MDSC in microenvironment of head and neck cancer

MDSC在头颈癌微环境中的免疫抑制作用

• 批准号: 21791606
• 负责人: YAMAMOTO Takanori
• 金额: $ 2.75万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791606/
• 关键词: 頭頸部外科学; MDSC; 免疫抑制; CD14+HLA-DR+; 制御性T細胞; CD14+HLA-DR-; TGF-β; 腫瘍微小環境

Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.

骨髓源性抑制细胞（MDSC）是一个异质性细胞群，具有通过多种机制抑制免疫应答的潜能。用HLA-DR标记物检测肿瘤患者外周血中MDSC。本研究探讨了头颈部鳞状细胞癌（SCCHN）患者CD 14 +HLA-DR_2细胞的比例和特征。分选的CD 14 +HLA-DR_细胞能够有效地抑制抗CD 28刺激的T细胞的增殖和IFN-α的产生，表明CD 14 +HLA-DR_细胞作为有效的免疫抑制细胞，特别有助于SCCHN患者的肿瘤从宿主免疫系统逃逸。

项目成果

A case of idiopathic hypereosinophilic syndrome with sinusitis and granulation tissue in the pharynx.

伴有鼻窦炎和咽部肉芽组织的特发性嗜酸性粒细胞增多综合征一例。

• 发表时间: 2009
• 作者: Yamamoto T;et al.
• 通讯作者: et al.

Analysis of Helper T Cell Responses to Cry j 1-Derived Peptides in Patients with Nasal Allergy: Candidate for Peptide-Based Immunotherapy of Japanese Cedar Pollinosis

• DOI: 10.2332/allergolint.08-oa-0008
• 发表时间: 2009-03-01
• 期刊: Allergology International
• 影响因子: 6.8
• 作者: Masuyama, Keisuke;Chikamatsu, Kazuaki;Endo, Shuichiro
• 通讯作者: Endo, Shuichiro

頭頸部扁平上皮癌患者の免疫抑制に及ぼすmyeloid-derived suppressor cellの役割

髓源性抑制细胞在头颈鳞状细胞癌患者免疫抑制中的作用

• 发表时间: 2011
• 作者: 近松一朗;他
• 通讯作者: 他

スギ花粉症に対するボツリヌス治療の有効性の検討(E-BOAT Study 2)

肉毒杆菌治疗雪松花粉病的有效性检验（E-BOAT 研究 2）

• 发表时间: 2010
• 作者: 上條篤;他
• 通讯作者: 他

Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck

• DOI: 10.1111/j.1349-7006.2012.02248.x
• 发表时间: 2012-06-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Chikamatsu, Kazuaki;Sakakura, Koichi;Masuyama, Keisuke
• 通讯作者: Masuyama, Keisuke