Clarification of phase variation and severity of Streptococcus pneumoniae with acute otitis media.

急性中耳炎患儿中耳液中分离的不透明期肺炎链球菌的检出率与鼻咽液中分离的不透明期肺炎链球菌的检出率差异很大。我们评估了3例急性中耳炎患者的临床分离株，分析了中耳液和鼻咽拭子分离株的期相变化和克隆性。在中耳液和鼻咽中观察到相同的PFGE模式，但在中耳液和鼻咽中表现出不同的相位变化模式。

The rate of opaque-phase strains S.pneumoniae isolated from middle ear fluids of pediatric patients with acute otitis media were highly variable than that from nasopharynx. We evaluated clinical isolates from three cases with acute otitis media regarding to the phase variation and clonality of strains isolated from middle ear fluids and nasopharyngeal swabs. We observed the identical PFGE pattern on the strains showing different phase variation pattern in the middle ear fluid and in the nasopharynx.