Sclerotherapy for Venous Malformations Using Infrared Fluorescence Imaging,

硬化疗法传统上用于超声或血管造影成像静脉畸形的目的。通过血管造影术，人们可以更容易地看到所有的结构，但通过重复治疗，会增加辐射暴露。最近，一种使用红外光和吲哚菁绿染料（ICG）来检测动脉、静脉和淋巴管的方法已经被开发出来。通过使用这种方式对静脉畸形进行成像，有效的硬化治疗可以通过静脉畸形的全面成像而无需放射治疗。在本研究中，共有62例患者接受了110次红外线荧光成像硬化治疗，以纠正血管畸形。与同时使用混合造影剂注射进行的数字减影血管造影相比，ICG成像更容易证实对唇部、眼睑和手部浅表畸形的有效硬化治疗。我们发现，与DSA相比，使用ICG成像指导浅表静脉畸形的硬化治疗安全有效且可重复，且无辐射风险，适用于医学界治疗静脉畸形的广泛采用。

Sclerotherapy has traditionally been used with ultrasonography or angiography for the purpose of imaging venous malformations. With angiography, one can more easily visualize all structures, but through repetitive treatment there is increased exposure to radiation. Recently, a procedure using infrared light and indocyanine green dye (ICG) to detect arteries, veins, and lymphatics has been developed. By using this modality to image venous malformations, effective sclerotherapy facilitated by full imaging of the venous malformation may be possible without radiation.In this reseach, a total of 62 patients underwent 110 sclerotherapy sessions with infrared fluorescence imaging to correct vascular malformations. As compared to digital subtraction angiography, which was performed simultaneously using mixed contrast agent injection, effective sclerotherapy of superficial malformations of the lips, palpebrae, and hands was easily confirmed with ICG imaging. We found that using ICG imaging to guide sclerotherapy for superficial venous malformations safely delivered effective and reproducible results as compared to DSA without the risk of radiation, and is applicable for broader adoption by the medical community for treating venous malformations.