The regulation of Fgf23 gene expression by inorganic phosphate

无机磷酸盐对Fgf23基因表达的调控

• 批准号: 21791782
• 负责人: TAMAMURA Yoshihiro
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791782/
• 关键词: Fgf23; 骨細胞; 無機リン; マウス; 高リン食; リン代謝

The expression of Fgf23 was regulated in bone in response to the change of serum concentration of inorganic phosphate. Calvaria was more sensitive than long bone to induce the expression of Fgf23. The expression of Fgf23 might not be regulated by direct effects of serum phosphate but by in concert with systemic factors. Cell types in bone should be elucidated in response to the change of the serum concentration of inorganic phosphate.

Fgf23在骨中的表达受血清无机磷浓度的影响。颅骨比长骨更敏感地诱导Fgf23的表达。Fgf23的表达可能不受血磷的直接影响，而与全身因素有关。骨细胞类型应根据血清无机磷浓度的变化来阐明。

项目成果

CCN3 and bone marrow cells

• DOI: 10.1007/s12079-009-0059-1
• 发表时间: 2009-06-01
• 期刊: JOURNAL OF CELL COMMUNICATION AND SIGNALING
• 影响因子: 4.1
• 作者: Katsube, Ken-ichi;Ichikawa, Saki;Yamaguchi, Akira
• 通讯作者: Yamaguchi, Akira

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