Serum calcium upregulates Fgf23 expression by Dickopf-1-mediated inhibition of Wnt/beta-catenin signaling in bone

FGF23是一种由骨细胞分泌的磷酸因子。FGF23在磷酸盐代谢中起中心作用，低血磷症患者血清FGF23水平升高证明了这一点。FGF23的转录后修饰已被广泛研究，但其转录调控机制尚不完全清楚。在这项研究中，我们证明了血清钙通过Dickopf-1介导的抑制Wnt/β-catenin信号在骨中的表达来调节FGF23的表达。这一结果为利用抗Dickpof-1抗体治疗低磷血症提供了新的可能性。

Fgf23 is a phosphaturic factor which is secreted from osteocytes in bone. Fgf23 plays a central role for phosphate metabolism as demonstrated by elevated serum levels of Fgf23 in hypophosphatemic diseases. Post-transcriptional modification of Fgf23 is extensively studied, however mechanisms of transcriptional regulation of Fgf23 are not fully understood. In this study, we demonstrated that serum calcium regulates Fgf23 expression by Dickopf-1-mediated inhibition of Wnt/beta-catenin signaling in bone. This result will provide the possibilities of a new therapy for hypophosphatemic diseases by using anti-Dickpof-1 antibody.