The relationship of intraepithelial blood vessels and NBI system in oral borderline malignancies.

口腔交界性恶性肿瘤上皮内血管与NBI系统的关系

• 批准号: 21791981
• 负责人: FUNAYAMA Akinori
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791981/
• 关键词: 臨床腫瘍学; 口腔粘膜悪性境界病変; 上皮内癌; 上皮内血管; NBI

Blood capillary vessels within the epithelial zone(IEBVs) of oral borderline malignancies including epithelial dysplasia and carcinoma in-situ(CIS) were examined by immunohistochemistry for CD31 and type IV collagen. IEBVs increased in number significantly in CIS. It was revealed that narrow band imaging(NBI), that is established to visualize abnormal microvascular patterns was a effective tool for differential diagnosis of oral borderline malignancies and decision of a adequate safety margin.

应用免疫组织化学方法检测口腔交界性恶性肿瘤上皮异型增生和原位癌组织中CD31和IV型胶原的表达。在独联体国家，感染性乙型肝炎病毒的数量显著增加。结果表明，窄带成像（NBI），这是建立可视化异常微血管模式是一个有效的工具，口腔交界性恶性肿瘤的鉴别诊断和决定一个足够的安全边界。