Suppressive effect of invasion and metastasis of oral squamous cell carcinoma by maspin expression

口腔鳞状细胞癌（OSCC）中Maspin的表达率为64.8%。maspin阳性表达的患者预后明显较好。而maspin在侵袭模式（Yamamoto-Kohama标准）4D型中表达较低，具有较高的侵袭潜力。此外，在uPA/uPAR系统中，Maspin表达与uPA/uPAR表达呈负相关。uPA(+)/uPAR(+)/Maspin（-）表达模式比其他侵袭性分级的OSCC表现出更强的侵袭潜力和最差的生存率。

Maspin expression in oral squamous cell carcinoma(OSCC) was detected in 64.8%. Patients with positive maspin expression had a significantly better prognosis. In contrast, maspin expression was lower in mode of invasion(Yamamoto-Kohama Critria) 4D type with high invasive potential. Moreover, Maspin expression showed a negative correlation with uPA/uPAR expression in the uPA/uPAR system. Expression pattern, uPA(+)/uPAR(+)/Maspin(-), exhibited a stronger invasive potential and the worst survival rate than other invasive grades of OSCC.