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Histological analysis of a molecule involved in development of function for eating and swallowing

对参与进食和吞咽功能发育的分子进行组织学分析

基本信息

批准号：
21792050
负责人：
TAKASAKI Chihiro
金额：
$ 2.75万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2010
项目状态：
已结题

项目摘要

Perineuronal oligodendrocytes are unmyelinating oligodendrocytes attaching to large neurons in various neural regions. However, little is known about their cellular characteristics. In this study, we examined their cytochemical properties in the mouse cerebral cortex. Almost all perineuronal oligodendrocytes expressed glia-specific or glia-enriched metabolic enzymes. Interestingly, they attached more to glutamatergic principal neurons, when the cerebral cortex develops and maturates. These cytochemical properties suggest that perineuronal oligodendrocytes are so differentiated as to fulfill metabolic support to the associating principal cortical neurons.

神经元周围少突胶质细胞是附着在各种神经区域的大神经元上的无髓鞘少突胶质细胞。然而，人们对它们的细胞特征知之甚少。在这项研究中，我们研究了它们在小鼠大脑皮层的细胞化学特性。几乎所有的神经元周围少突胶质细胞表达胶质细胞特异性或胶质细胞富集的代谢酶。有趣的是，当大脑皮层发育成熟时，它们更多地附着在多巴胺能主神经元上。这些细胞化学性质表明，神经元周少突胶质细胞分化，以履行相关的主要皮层神经元的代谢支持。