Histological analysis of molecules participating in eating adjustment for the development period

参与发育期饮食调节的分子的组织学分析

• 批准号: 23792405
• 负责人: TAKASAKI Chihiro
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792405/
• 关键词: 摂食; マウス; 摂食調節; 視床下部

We analyzed molecules that adjust eating function in the wild-type mice brain. We found that cerebellin 1(Cbln1) mRNA, glutamate transporter VGluT2 mRNA and CB1 mRNA were coexpressed in the satiety center of the brain partly each. Therefore, it was suggested that Cbln1 and CB1 were distributed in the glutamatergic neuron, and participated in the adjustment of the eating function.

我们分析了野生型小鼠大脑中调节进食功能的分子。结果发现，小脑素1（Cbln 1）mRNA、谷氨酸转运体VGluT2 mRNA和CB 1 mRNA在饱腹中枢各有一部分共表达。提示Cbln 1和CB 1可能分布于大鼠的摄食能神经元，参与摄食功能的调节。