Detection of new ion channel in the nerve terminals of the periodontal ligament

牙周膜神经末梢新离子通道的检测

• 批准号: 21792064
• 负责人: HARADA Fumiko
• 金额: $ 2.83万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792064/
• 关键词: 歯学; 神経科学; イオンチャネル; ASIC3; ルフィニ神経終末; 歯根膜; 三叉神経節; 機械受容器; 機械感覚; 歯根膜神経終末; 機械受容

The acid-sensing ion channel 3 (ASIC3) has been reported to participate in acid sensing, mechanosensation, and nociception. The present study examined the expression of ASIC3 in the lingual periodontal ligament of mouse incisors by immunohistochemistry. Furthermore, the expression of ASIC3 in the trigeminal ganglion-which innervates the periodontal ligament-was investigated at protein and mRNA levels. These findings suggest that ASIC3 functions as a molecule for mechanosensation in the periodontal Ruffini endings.

酸敏感离子通道3（ASIC 3）参与酸敏感、机械感觉和伤害感受。本研究采用免疫组织化学方法检测ASIC3在小鼠切牙舌侧牙周膜中的表达。此外，在蛋白质和mRNA水平上研究了支配牙周韧带的三叉神经节中ASIC 3的表达。这些发现表明，ASIC3的功能作为一个分子的机械感觉牙周Ruffini结束。

项目成果

Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors

• DOI: 10.1016/j.neulet.2010.11.023
• 发表时间: 2011-01-20
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Rahman, Farhana;Harada, Fumiko;Maeda, Takeyasu
• 通讯作者: Maeda, Takeyasu

GDNF expression in terminal schwann cells associated with the periodontal Ruffini endings of the rat incisors during nerve regeneration.

神经再生过程中与大鼠门牙牙周鲁菲尼末梢相关的终末雪旺细胞中 GDNF 的表达。

• 发表时间: 2009
• 期刊: Anatomical Record 292
• 作者: Ohishi M;Harada F;et al.
• 通讯作者: et al.

Acid-Sensing Ion Channel 3 Expression in the Periodontal Ruffini Endings.

牙周 Ruffini 末梢中酸敏感离子通道 3 的表达。

• 发表时间: 2010
• 作者: Rahman F;Harada F;Kawano Y;Ohishi M;Nozawa-Inoue K;Saito I;Maeda T.
• 通讯作者: Maeda T.

Acid-Sensing Ion Channel 3 Expression in the Periodontal Ruffi ni Endings.

牙周 Ruffini 末梢中酸敏感离子通道 3 的表达。

• 发表时间: 2010
• 作者: Rahman F;Harada F;Kawano Y;Ohishi M;Nozawa-Inoue K;Saito I;Maeda T.
• 通讯作者: Maeda T.

Multiple neurotrophins involve regeneration of the periodontal Ruffini endings after transection of rat inferior alveolar nerve.

多种神经营养因子涉及大鼠下牙槽神经横断后牙周鲁菲尼末梢的再生。

• 发表时间: 2010
• 作者: Ohishi M;Harada F;Maeda T.
• 通讯作者: Maeda T.