Bioorganic Studies on the Key Natural Products Focused on Marine Symbiosis

我们调查了海洋生态系统中服务于宿主动物与共生体之间的共生关系或作为捕食者防御物质的具有生物活性的关键天然产物。我们利用独特的降解反应测定了甲藻共生代谢产物共生物内酯的平面结构和部分相对结构。我们还(A)确定了该化合物是一种有效的N型钙通道激动剂。我们发现一种珊瑚的提取物具有很强的炎症活性，并成功地分离出色胺和一种水溶性小分子作为活性物质。

We investigated the bioactive key natural products that serve the symbiotic relationship between host animals and symbionts or act as defense substances from predators in marine ecosystem. We determined the planar and partial relative structures of symbiodinolide, metabolite from a symbiotic dinoflagellate, by using unique degradation reactions.Wealso(a) established that this compound was a potent N-type Ca channel agonist. We discovered that the extract of an Alcyonarian coral shows potent inflammatory activity, and successfully isolated tryptamine and a water-soluble small molecule as active substances.