Development of novel adsorbent with adjustable pore entrance size and application to temperature-responsive separation system

通过在吸附剂的外表面固定一种温度响应性聚合物（该聚合物的体积随溶液温度的变化而变化），开发了一种新型的吸附剂。该材料在较低温度（25℃）下对分子的吸附和解吸与溶液的pH可逆，而在较高温度（40℃）下不对分子进行吸附和解吸，与溶液的pH无关。此外，还发现在聚合物合成过程中加入交联剂制备的吸附剂的相变温度向高温移动了约5℃。结果表明，该温度响应型吸附剂可作为药物释放载体和温度梯度色谱柱填充剂。

A novel adsorbent was developed by immobilizing a temperature-responsive polymer (the volume of this polymer changes with changing in the solution temperature) on the external surface of adsorbent. This material adsorbed and desorbed molecules with pH of the solution reversibly at lower temperature of 25℃, while it did not adsorb and desorb molecules independent of pH of the solution at higher temperature of 40℃. Also, it was found this phase-transition temperature shifted by about 5℃ to the higher temperature for the adsorbent prepared by the addition of cross-linking agent during the polymer synthesis. From these results, this temperature-responsive adsorbent can be applied to the carrier for drug delivery system and column packing agent for temperature-gradient chromatography.