Development of artificial antibodies to molecular targets of cancer cells
Development of artificial antibodies to molecular targets of cancer cells
批准号:
21659306
负责人:
NAKAMURA Masafumi
金额:
$2.04万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The goal of the study is designing a peptide affinity for cancer-related molecule. To validate the anti-tumor effect, subject to the(Hh) signal Hedgehog, Small peptides with affinity for cell surface receptor Ptched1 were designated. Its effect on cancer cells were examined using breast and pancreatic cancer cells. We probed that synthesized peptides suppressed Hh signaling activity and cancer cell proliferation in vitro and vivo.
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Hedgehog(Hh)シグナル系を標的とした「乳癌幹細胞制御療法」の可能性
针对Hedgehog (Hh)信号系统的“乳腺癌干细胞控制疗法”的可能性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Onoda M, Yoshimura K, Aoki H, Ikeda Y, Morikage N, et al., 田中晴生]
通讯作者:
田中晴生
腫瘍幹細胞cancer stem cellを標的とした乳癌治療法の開発
针对癌症干细胞的乳腺癌治疗的发展
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[田中晴生, 中村雅史, 宗崎正恵, 甲斐昌也, 亀田千津, 久保真, 田中雅夫, 片野光男]
通讯作者:
片野光男
DOI:
10.1007/s00535-011-0507-6
发表时间:
2012-04-01
期刊:
JOURNAL OF GASTROENTEROLOGY
影响因子:
6.3
作者:
[Nakamura, Masafumi, Tanaka, Haruo, Okada, Hidechika]
通讯作者:
Okada, Hidechika
:Hedgehogシグナルに対する低分子ペプチドを用いた制御法の開発
:开发使用低分子量肽的Hedgehog信号控制方法
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tang, E. H., Aoki, H., et al, 中村雅史]
通讯作者:
中村雅史
Hedgehogシグナルを標的とした治療開発
针对 Hedgehog 信号的治疗开发
DOI:
--
发表时间:
2012
期刊:
腫瘍内科
影响因子:
--
作者:
[小暮公孝, 他, 中村雅史]
通讯作者:
中村雅史
共 8 条
Analysis and remodeling of immune microenvironment using pancreatic cancer organoids after treatment
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批准号:21K19531
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2021
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负责人:NAKAMURA Masafumi
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依托单位:
Elucidation of the intratumor therapeutic resistance heterogeneity using single-cell transcriptome of the PDX libraries with pancreatic cancer.
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批准号:19H03732
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2019
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负责人:NAKAMURA Masafumi
-
依托单位:
Elucidation and control of the mechanism of cluster invasion by partialEMT using pancreatic cancer organoids
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批准号:19K22663
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2019
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负责人:NAKAMURA Masafumi
-
依托单位:
Novel method to visualize invasion and metastasis of pancreatic cancer using in vitro microenvironment model constructed by 3D bioprinter
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批准号:17K19605
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
-
财政年份:2017
-
负责人:NAKAMURA Masafumi
-
依托单位:
Identification of the organ-specific cancer leading cells and regulation of the tumor micro-environment remodeling which leads to cancer cell metastasis.
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批准号:16H05418
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
-
财政年份:2016
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负责人:NAKAMURA Masafumi
-
依托单位:
Isolation and regulation of organ specific cancer stem cell
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批准号:20390346
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.65万
-
财政年份:2008
-
负责人:NAKAMURA Masafumi
-
依托单位:
Development the new cancer treatment targeting the regulation system of cancer stem cells
-
批准号:18390350
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
-
财政年份:2006
-
负责人:NAKAMURA Masafumi
-
依托单位:
Development of new cancer therapy by regulating cytoskeleton and cancer-cell transformation
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批准号:16591326
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
-
负责人:NAKAMURA Masafumi
-
依托单位:
Traditional Industry and Regional Economy : A Comparative Study on Oshima-tsumugi Industry and Yuki-tsumugi Industry
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批准号:04630031
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.83万
-
财政年份:1992
-
负责人:NAKAMURA Masafumi
-
依托单位:
Industrial Structure in Depopulated Area and Effectiveness of Development Policies
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批准号:63301082
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$5.38万
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财政年份:1988
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负责人:NAKAMURA Masafumi
-
依托单位:
海外基金